Publication Name	World Journal of Gastroenterology
Manuscript ID	3342
Country	Belgium

Received	2013-04-24 09:09
Peer-Review Started	2013-04-24 11:02
To Make the First Decision	2013-06-24 10:28
Return for Revision	2013-07-01 13:31
Revised	2013-08-27 19:26
Second Decision	2013-09-17 09:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 10:27
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-12-29 23:47
Typeset the Manuscript	2014-01-17 10:10
Publish the Manuscript Online	2014-02-17 14:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Autobiography
Article Title	Regulation of hepatic EAAT-2 glutamate transporter expression in human liver cholestasis
Manuscript Source	Invited Manuscript
All Author List	Mustapha Najimi, Xavier Stéphenne, Christine Sempoux and Etienne Sokal
Funding Agency and Grant Number
Corresponding Author	Mustapha Najimi, PhD, Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Avenue Mounier 52, Brussels 1200, Belgium. mustapha.najimi@uclouvain.be
Key Words	Glutamate transport; Hepatocyte; Bile duct ligation; Cholestasis; Biliary atresia
Core Tip	The aim of the current study was to demonstrate the role of glutamate transport, the most abundant intracellular hepatic amino acid, in liver cholestasis. The study was conducted in vitro using HepG2 cells as well as the livers of bile duct ligated rats and human cholestasis specimens. The principal data revealed that the activity and expression of EAAT2-mediated glutamate transport were altered both in vitro and in vivo. This supports the involvement of glutamate transporters, as an indirect liver response and/or as a direct hepatic target, in restoring intracellular pools of this amino acid which are probably altered after cholestasis.
Publish Date	2014-02-17 14:01
Citation	Najimi M, Stéphenne X, Sempoux C, Sokal E. Regulation of hepatic EAAT-2 glutamate transporter expression in human liver cholestasis. World J Gastroenterol 2014; 20(6): 1554-1564
URL	http://www.wjgnet.com/1007-9327/full/v20/i6/1554.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i6.1554

Full Article (PDF)	WJG-20-1554.pdf
Full Article (Word)	WJG-20-1554.doc
Manuscript File	3342-Review.doc
Answering Reviewers	3342-Answering reviewers.pdf
Copyright License Agreement	3342-Copyright assignment.pdf
Peer-review Report	3342-Peer review(s).pdf
Scientific Editor Work List	3342-Scientific editor work list.doc