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9/3/2014 10:14:00 AM | Browse: 421 | Download: 376
Publication Name World Journal of Gastroenterology
Manuscript ID 3342
Country/Territory Belgium
Received
2013-04-24 09:09
Peer-Review Started
2013-04-24 11:02
To Make the First Decision
2013-06-24 10:28
Return for Revision
2013-07-01 13:31
Revised
2013-08-27 19:26
Second Decision
2013-09-17 09:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-09-17 10:27
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2013-12-29 23:47
Typeset the Manuscript
2014-01-17 10:10
Publish the Manuscript Online
2014-02-17 14:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Autobiography
Article Title Regulation of hepatic EAAT-2 glutamate transporter expression in human liver cholestasis
Manuscript Source Invited Manuscript
All Author List Mustapha Najimi, Xavier Stéphenne, Christine Sempoux and Etienne Sokal
Funding Agency and Grant Number
Corresponding author Mustapha Najimi, PhD, Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Avenue Mounier 52, Brussels 1200, Belgium. mustapha.najimi@uclouvain.be
Keywords Glutamate transport; Hepatocyte; Bile duct ligation; Cholestasis; Biliary atresia
Core Tip The aim of the current study was to demonstrate the role of glutamate transport, the most abundant intracellular hepatic amino acid, in liver cholestasis. The study was conducted in vitro using HepG2 cells as well as the livers of bile duct ligated rats and human cholestasis specimens. The principal data revealed that the activity and expression of EAAT2-mediated glutamate transport were altered both in vitro and in vivo. This supports the involvement of glutamate transporters, as an indirect liver response and/or as a direct hepatic target, in restoring intracellular pools of this amino acid which are probably altered after cholestasis.
Publish Date 2014-02-17 14:01
Citation Najimi M, Stéphenne X, Sempoux C, Sokal E. Regulation of hepatic EAAT-2 glutamate transporter expression in human liver cholestasis. World J Gastroenterol 2014; 20(6): 1554-1564
Url http://www.wjgnet.com/1007-9327/full/v20/i6/1554.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i6.1554
Full Article (PDF) WJG-20-1554.pdf
Full Article (Word) WJG-20-1554.doc
Manuscript File 3342-Review.doc
Answering Reviewers 3342-Answering reviewers.pdf
Copyright License Agreement 3342-Copyright assignment.pdf
Peer-review Report 3342-Peer review(s).pdf
Scientific Editor Work List 3342-Scientific editor work list.doc