Publication Name	World Journal of Gastroenterology
Manuscript ID	33423
Country	China

Received	2017-02-08 09:57
Peer-Review Started	2017-02-09 09:12
First Decision by Editorial Office Director
Return for Revision	2017-03-21 11:33
Revised	2017-03-27 10:50
Publication Fee Transferred	2017-04-27 19:01
Second Decision by Editor	2017-04-11 16:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-04-12 18:06
Articles in Press	2017-04-12 18:06
Edit the Manuscript by Language Editor	2017-05-13 11:08
Typeset the Manuscript	2017-06-28 02:29
Publish the Manuscript Online	2017-07-07 11:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	miR-29a promotes hepatitis B virus replication and expression by targeting SMARCE1 in hepatoma carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Jie Wu, Ya Zhuo, Yan-Cai Zhou, Xin-Wei Wang, Yan-Ping Wang, Chang-Yun Si and Xi-Hong Wang
Funding Agency and Grant Number
Corresponding Author	Xi-Hong Wang, Chief Physician, Department of Infectious Disease, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Xinxiang 453100, Henan Province, China. wangxinh621@sina.com
Key Words	miR-29a; SMARCE1; Hepatitis B surface antigen; Hepatitis B virus replication; Hepatitis B e antigen
Core Tip	Although aberrant miR-29a expression has been found to be involved in the process of hepatitis B virus (HBV) infection, its underlying mechanism remains unclear. In this study, we analyzed the expression levels of miR-29a in HBV-infected HepG2.2.15 cells. Our results indicated that miR-29a expression was up-regulated in HBV-associated hepatocellular carcinoma cells. In addition, SMARCE1 was confirmed to be a functional target of miR-29a. miR-29a promoted HBV replication and expression through directly regulating SMARCE1. These findings provide potential therapeutic targets for patients with HBV infection.
Publish Date	2017-07-07 11:41
Citation	Wu HJ, Zhuo Y, Zhou YC, Wang XW, Wang YP, Si CY, Wang XH. miR-29a promotes hepatitis B virus replication and expression by targeting SMARCE1 in hepatoma carcinoma. World J Gastroenterol 2017; 23(25): 4569-4578
URL	http://www.wjgnet.com/1007-9327/full/v23/i25/4569.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i25.4569

Full Article (PDF)	WJG-23-4569.pdf
Full Article (Word)	WJG-23-4569.doc
Manuscript File	33423-Review.doc
Answering Reviewers	33423-Answering reviewers.pdf
Audio Core Tip	33423-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33423-Conflict-of-interest statement.pdf
Copyright License Agreement	33423-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	33423-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	33423-Language certificate.pdf
Peer-review Report	33423-Peer-review(s).pdf
Scientific Misconduct Check	33423-Scientific misconduct check.pdf
Scientific Editor Work List	33423-Scientific editor work list.pdf