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Articles Published Processes
7/12/2017 6:45:23 AM | Browse: 965 | Download: 1812
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Received |
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2017-02-10 09:48 |
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Peer-Review Started |
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2017-02-11 21:40 |
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To Make the First Decision |
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2017-03-16 11:51 |
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Return for Revision |
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2017-03-21 11:32 |
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Revised |
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2017-04-23 23:20 |
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Second Decision |
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2017-05-15 08:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-05-19 08:25 |
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Articles in Press |
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2017-05-19 08:25 |
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Publication Fee Transferred |
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2017-05-23 13:25 |
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Edit the Manuscript by Language Editor |
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2017-06-17 01:32 |
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Typeset the Manuscript |
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2017-06-28 10:02 |
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Publish the Manuscript Online |
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2017-07-12 06:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of EPEC endotoxin and bifidobacteria on intestinal barrier function through modulation of toll-like receptor 2 and toll-like receptor 4 expression in intestinal epithelial cell-18
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xia Yang, Xian-Chun Gao, Jun Liu and Hong-Yu Ren |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medjaden Academy & Research Foundation for Young Scientists |
MJA20170410 |
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| Corresponding Author |
Hong-Yu Ren, MD, PhD, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan 430022, Hubei Province, China. hongyur@hotmail.com |
| Key Words |
Bifidobacteria; Intestinal barrier function; Intestinal epithelial cells |
| Core Tip |
toll-like receptors (TLRs) are key components of the innate immune system that trigger antimicrobial host defense responses. EPEC promoted the expression of toll-like receptors 2 (TLR2) and TLR4 and increased cell membrane permeability, where as bifidobacteria inhibited the expression of TLR2 and TLR4 and prevented TLR-mediated inflammation. Therefore, bifidobacteria can potentially play a protective role by inhibiting inflammation and preventing penetration of pathogenic bacteria in patients with inflammatory bowel disease. |
| Publish Date |
2017-07-12 06:45 |
| Citation |
Yang X, Gao XC, Liu J, Ren HY. Effect of EPEC endotoxin and bifidobacteria on intestinal barrier function through modulation of toll-like receptor 2 and toll-like receptor 4 expression in intestinal epithelial cell-18. World J Gastroenterol 2017; 23(26): 4744-4751 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i26/4744.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i26.4744 |
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