Publication Name	World Journal of Biological Chemistry
Manuscript ID	33436
Country	United States

Received	2017-02-08 09:20
Peer-Review Started	2017-02-12 16:52
To Make the First Decision	2017-03-08 09:43
Return for Revision	2017-03-10 17:25
Revised	2017-04-03 22:09
Second Decision	2017-04-29 16:49
Accepted by Journal Editor-in-Chief	2017-04-29 16:55
Accepted by Executive Editor-in-Chief	2017-05-05 18:29
Articles in Press	2017-05-05 18:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-16 01:39
Publish the Manuscript Online	2017-05-18 04:11

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Identification of neuron selective androgen receptor inhibitors
Manuscript Source	Invited Manuscript
All Author List	Maya Otto-Duessel, Ben Yi Tew, Steven Vonderfecht, Roger Moore and Jeremy O Jones
Funding Agency and Grant Number
Corresponding Author	Jeremy O Jones, PhD, Assistant Professor, Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Rd, Beckman 2310, Duarte, CA 91010, United States. jjones@coh.org
Key Words	Androgen receptor; Selective androgen receptor modulator; Spinal and bulbar muscular atrophy; Kennedy’s disease
Core Tip	Kennedy’s disease is caused by genetic expansion of the polyglutamine tract in the androgen receptor (AR). There is debate over whether the toxicity is due to expression of this mutant AR in motor neurons, muscle cells, or both. We have identified neuron-specific AR inhibitors, which could be used to help answer this question, and might be useful in the treatment or prevention of Kennedy’s disease. These inhibitors function via FOXM1 and beta-catenin, which are shown to have important roles in the regulation of AR in neurons.
Publish Date	2017-05-18 04:11
Citation	Otto-Duessel M, Tew BY, Vonderfecht S, Moore R, Jones JO. Identification of neuron selective androgen receptor inhibitors. World J Biol Chem 2017; 8(2): 138-150
URL	http://www.wjgnet.com/1949-8454/full/v8/i2/138.htm
DOI	http://dx.doi.org/10.4331/wjbc.v8.i2.138

Full Article (PDF)	WJBC-8-138.pdf
Full Article (Word)	WJBC-8-138.doc
Manuscript File	33436-Review.doc
Answering Reviewers	33436-Answering reviewers.pdf
Audio Core Tip	33436-Audio core tip.mp3
Biostatistics Review Certificate	Biostatistics_Statement_20170208011421.doc
Conflict-of-Interest Disclosure Form	33436-Conflict-of-interest statement.pdf
Copyright License Agreement	33436-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	Grant_Application_Form_20170208011338.doc
Institutional Animal Care and Use Committee Approval Form or Document	33436-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	33436-Institutional review board statement.pdf
Peer-review Report	33436-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33436-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	33436-Scientific misconduct check.pdf
Scientific Editor Work List	33436-Scientific editor work list.pdf