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Articles Published Processes
6/20/2017 12:12:53 PM | Browse: 1014 | Download: 1994
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Received |
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2017-02-09 09:02 |
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Peer-Review Started |
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2017-02-09 16:32 |
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To Make the First Decision |
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2017-03-16 11:51 |
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Return for Revision |
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2017-03-21 11:31 |
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Revised |
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2017-03-30 22:23 |
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Second Decision |
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2017-05-04 17:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-05-09 16:58 |
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Articles in Press |
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2017-05-09 16:58 |
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Publication Fee Transferred |
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2017-05-10 14:01 |
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Edit the Manuscript by Language Editor |
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2017-05-29 00:03 |
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Typeset the Manuscript |
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2017-06-13 12:00 |
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Publish the Manuscript Online |
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2017-06-20 12:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shan Zhuang, Yong-Mei Jian and Yong-Ning Sun |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Committee of Science and Technology |
D401905000 |
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| Corresponding Author |
Yong-Ning Sun, PhD, Director, Department of Traditional Chinese Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, China. ynsun@sjtu.edu.cn |
| Key Words |
Diabetes; Gastric cancer; Liuwei Dihuang Pill; Insulin; Insulin-like growth factor |
| Core Tip |
Type 2 diabetes is reported to increase risk of gastric carcinogenesis, partly by hyperinsulinemia, hyperglycemia, excessive activation of insulin-like growth factor (IGF)-1, and disorders of adipokines. In this study, we demonstrated that Liuwei Dihuang Pill decreased the risk of gastric tumorigenesis in type 2 diabetic mice by alleviating insulin resistance and decreasing IGF-1 and insulin activity, followed by down-regulation of the IGF-1/AKT signaling pathway. The improvement in adiponectin and leptin may also contribute to the effects. |
| Publish Date |
2017-06-20 12:12 |
| Citation |
Zhuang S, Jian YM, Sun YN. Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice. World J Gastroenterol 2017; 23(23): 4233-4242 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i23/4233.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i23.4233 |
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