Publication Name	World Journal of Gastroenterology
Manuscript ID	33455
Country	China

Received	2017-02-09 09:02
Peer-Review Started	2017-02-09 16:32
First Decision by Editorial Office Director
Return for Revision	2017-03-21 11:31
Revised	2017-03-30 22:23
Publication Fee Transferred	2017-05-10 14:01
Second Decision by Editor	2017-05-04 17:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-05-09 16:58
Articles in Press	2017-05-09 16:58
Edit the Manuscript by Language Editor	2017-05-29 00:03
Typeset the Manuscript	2017-06-13 12:00
Publish the Manuscript Online	2017-06-20 12:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Integrative & Complementary Medicine
Manuscript Type	Basic Study
Article Title	Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice
Manuscript Source	Unsolicited Manuscript
All Author List	Shan Zhuang, Yong-Mei Jian and Yong-Ning Sun
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Committee of Science and Technology D401905000
Corresponding Author	Yong-Ning Sun, PhD, Director, Department of Traditional Chinese Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, China. ynsun@sjtu.edu.cn
Key Words	Diabetes; Gastric cancer; Liuwei Dihuang Pill; Insulin; Insulin-like growth factor
Core Tip	Type 2 diabetes is reported to increase risk of gastric carcinogenesis, partly by hyperinsulinemia, hyperglycemia, excessive activation of insulin-like growth factor (IGF)-1, and disorders of adipokines. In this study, we demonstrated that Liuwei Dihuang Pill decreased the risk of gastric tumorigenesis in type 2 diabetic mice by alleviating insulin resistance and decreasing IGF-1 and insulin activity, followed by down-regulation of the IGF-1/AKT signaling pathway. The improvement in adiponectin and leptin may also contribute to the effects.
Publish Date	2017-06-20 12:12
Citation	Zhuang S, Jian YM, Sun YN. Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice. World J Gastroenterol 2017; 23(23): 4233-4242
URL	http://www.wjgnet.com/1007-9327/full/v23/i23/4233.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i23.4233

Full Article (PDF)	WJG-23-4233.pdf
Full Article (Word)	WJG-23-4233.doc
Manuscript File	33455-Review.doc
Answering Reviewers	33455-Answering reviewers.pdf
Audio Core Tip	33455-Audio core tip.mp3
Biostatistics Review Certificate	33455-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	33455-Conflict-of-interest statement.pdf
Copyright License Agreement	33455-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	33455-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	33455-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	33455-Language certificate.pdf
Peer-review Report	33455-Peer-review(s).pdf
Scientific Misconduct Check	33455-Scientific misconduct check.pdf
Scientific Editor Work List	33455-Scientific editor work list.pdf