Publication Name	World Journal of Gastroenterology
Manuscript ID	33465
Country	China

Received	2017-02-10 09:07
Peer-Review Started	2017-02-14 16:39
First Decision by Editorial Office Director
Return for Revision	2017-03-31 16:00
Revised	2017-04-13 18:38
Publication Fee Transferred	2017-06-20 02:22
Second Decision by Editor	2017-05-04 17:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-05-09 16:59
Articles in Press	2017-05-09 16:59
Edit the Manuscript by Language Editor	2017-07-09 22:50
Typeset the Manuscript	2017-07-20 09:28
Publish the Manuscript Online	2017-07-28 08:16

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Biology
Manuscript Type	Basic Study
Article Title	Fibroblast-derived CXCL12/SDF-1α promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Chi Ma, Xiao-Wen Sun, He Su, Quan Chen, Tian-Kang Guo, Yuan Li, Xiao-Chang Chen, Jin Guo, Zhen-Qiang Gong, Xiao-Dan Zhao and Jian-Bo Qi
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81260325 (to Ma JC)
Corresponding Author	Jia-Chi Ma, PhD, Department of General Surgery, Gansu Provincial People's Hospital, 204 Dong Gang West Road, Lanzhou 730000, Gansu Province, China. tsmjc@hotmail.com
Key Words	CXCL12/SDF-1α; CXCL6; Metastasis; PI3K/Akt/mTOR pathway; Colon cancer
Core Tip	This study has provided the first report of fibroblast-derived CXCL12 enhancement of CXCL6 secretion in colon cancer cells, and of both CXCL12 and CXCL6 co-operatively regulating metastasis through the PI3K/Akt/mTOR signaling pathway. Blockage of this pathway may be a potential anti-metastatic therapeutic target for patients with colon cancer. Our work might encourage further investigation into more potent angiogenesis modulating agents to improve the effectiveness of colon cancer therapies.
Publish Date	2017-07-28 08:16
Citation	Ma JC, Sun XW, Su H, Chen Q, Guo TK, Li Y, Chen XC, Guo J, Gong ZQ, Zhao XD, Qi JB. Fibroblast-derived CXCL12/SDF-1α promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer. World J Gastroenterol 2017; 23(28): 5167-5178
URL	http://www.wjgnet.com/1007-9327/full/v23/i28/5167.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i28.5167

Full Article (PDF)	WJG-23-5167.pdf
Full Article (Word)	WJG-23-5167.doc
Manuscript File	33465-Review.doc
Answering Reviewers	33465-Answering reviewers.pdf
Audio Core Tip	33465-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33465-Conflict-of-interest statement.pdf
Copyright License Agreement	33465-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	33465-Language certificate.pdf
Peer-review Report	33465-Peer-review(s).pdf
Scientific Misconduct Check	33465-Scientific misconduct check.pdf
Scientific Editor Work List	33465-Scientific editor work list.pdf