Publication Name	World Journal of Nephrology
Manuscript ID	33475
Country	United States

Received	2017-02-10 12:04
Peer-Review Started	2017-02-15 11:31
To Make the First Decision	2017-03-08 09:46
Return for Revision	2017-03-10 17:30
Revised	2017-03-30 21:56
Second Decision	2017-05-08 15:23
Accepted by Journal Editor-in-Chief	2017-05-08 16:10
Accepted by Company Editor-in-Chief	2017-05-15 05:49
Articles in Press	2017-05-15 05:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-29 01:03
Publish the Manuscript Online	2017-06-30 06:51

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Basic Study
Article Title	Tesevatinib ameliorates progression of polycystic kidney disease in rodent models of autosomal recessive polycystic kidney disease
Manuscript Source	Invited Manuscript
All Author List	William E Sweeney, Philip Frost and Ellis D Avner
Funding Agency and Grant Number	Funding Agency Grant Number the PKD research program is provided by the Children’s Research Institute, the Lillian Goldman Charitable Trust, Ellsworth Family and Children’s Foundation of Children’s Hospital and Health System of Wisconsin
Corresponding Author	Ellis D Avner, MD, Emeritus Professor of Pediatrics and Physiology, Founding Director, Children’s Research Institute, Children’s’ Hospital Health System of Wisconsin and the Medical College of Wisconsin, Medical College of Wisconsin, Suite C-510, Mailstop CCC C510, 999 North 92nd Street, Milwaukee, WI 53226, United States. bsweeney@mcw.edu
Key Words	Autosomal recessive; Autosomal dominant; Polycystic kidney disease; Therapy; Kinase inhibition; Multi-kinase inhibitor; Phosphorylation; Renal cysts; Biliary; G-protein coupled receptor
Core Tip	This study examined the effect of a multi-kinase inhibitor, tesevatinib (TSV) on cyst development and growth in rodent models of autosomal recessive polycystic kidney disease (ARPKD). Tesevatinib which targets epidermal growth factor receptors, Src and KDR is currently in clinical trials for autosomal dominant polycystic kidney disease (ADPKD) and given the molecular and cellular interactions of the ADPKD and ARPKD genes and proteins we sought to determine if TSV would ameliorate ARPKD in two well described models and an orthologous rat model of ARPKD phenocopy. Of particular interest was the effect of TSV’s inhibition of VEGFR2 or KDR during early post-natal development and renal maturation.
Publish Date	2017-06-30 06:51
Citation	Sweeney WE, Frost P, Avner ED. Tesevatinib ameliorates pro¬gression of polycystic kidney disease in rodent models of autosomal recessive polycystic kidney disease. World J Nephrol 2017; 6(4): 188-200
URL	http://www.wjgnet.com/2220-6124/full/v6/i4/188.htm
DOI	http://dx.doi.org/10.5527/wjn.v6.i4.188

Full Article (PDF)	WJN-6-188.pdf
Full Article (Word)	WJN-6-188.doc
Manuscript File	33475-Review.docx
Answering Reviewers	33475-Answering reviewers.pdf
Audio Core Tip	33475-Audio core tip.wav
Biostatistics Review Certificate	33475-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	33475-Conflict-of-interest statement.pdf
Copyright License Agreement	33475-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	33475-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	33475-Institutional animal care and use committee statement.pdf
Peer-review Report	33475-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33475-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	33475-Scientific misconduct check.pdf
Scientific Editor Work List	33475-Scientific editor work list.pdf