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Articles Published Processes
8/24/2017 2:02:46 AM | Browse: 1033 | Download: 2189
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Received |
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2017-02-13 14:17 |
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Peer-Review Started |
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2017-02-15 09:09 |
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To Make the First Decision |
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2017-03-08 09:46 |
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Return for Revision |
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2017-03-10 17:42 |
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Revised |
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2017-03-18 07:30 |
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Second Decision |
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2017-07-06 09:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-07-17 06:10 |
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Articles in Press |
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2017-07-17 06:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-08-18 07:54 |
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Publish the Manuscript Online |
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2017-08-24 02:02 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Phase Ⅰ/Ⅱ randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kam Sze Tsang, Chi Ping Stephanie Ng, Xian Lun Zhu, George Kwok Chu Wong, Gang Lu, Anil Tejbhan Ahuja, Ka Sing Lawrence Wong, Ho Keung Ng and Wai Sang Poon |
| Funding Agency and Grant Number |
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| Corresponding Author |
Wai Sang Poon, MD, Division of Neurosurgery, Department of Surgery, the Chinese University of Hong Kong, Prince of Wales Hospital, 30-32, Ngan Shing Road, Shatin, Hong Kong NA, China. wpoon@cuhk.edu.hk |
| Key Words |
Stroke; Intracerebral haemorrhage; Central nervous system; Mesenchymal stem cells; Cell therapy |
| Core Tip |
Contemporary treatments are ineffective in restoring lost neurological functions after stroke. Many stroke patients were noted to have lesions close to the sub-ventricular zone. The likely beneficial effects of mesenchymal stem cell (MSC) treatment might correlate with the spatial lesion, not part of the sub-ventricular zone where endogenous neurogenesis persists during adulthood, and indirect chaperon effects of MSC promote endogenous neuro-regeneration. We administered MSC intravenously to patients having severe neurological disability and presenting stable baseline scores one year after the onset of intracerebral haemorrhage to eliminate confounding attributes to the observation of MSC-me¬diated neurological recovery. |
| Publish Date |
2017-08-24 02:02 |
| Citation |
Tsang KS, Ng CPS, Zhu XL, Wong GKC, Lu G, Ahuja AT, Wong KSL, Ng HK, Poon WS. Phase Ⅰ/Ⅱ randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke. World J Stem Cells 2017; 9(8): 133-143 |
| URL |
http://www.wjgnet.com/1948-0210/full/v9/i8/133.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v9.i8.133 |
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