Publication Name	World Journal of Transplantation
Manuscript ID	33503
Country	United States

Received	2017-02-13 11:28
Peer-Review Started	2017-02-15 09:05
To Make the First Decision	2017-04-17 09:28
Return for Revision	2017-04-17 14:35
Revised	2017-06-28 14:57
Second Decision	2017-07-28 05:06
Accepted by Journal Editor-in-Chief	2017-07-28 09:42
Accepted by Executive Editor-in-Chief	2017-08-02 20:45
Articles in Press	2017-08-02 20:45
Publication Fee Transferred	2017-08-15 00:21
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-10-23 06:31
Publish the Manuscript Online	2017-10-23 07:26

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Observational Study
Article Title	Graft loss among renal-transplant recipients with early reduction of immunosuppression for BK viremia
Manuscript Source	Unsolicited Manuscript
All Author List	Marwan M Azar, Roland Assi, Aziz K Valika, David B Banach, Isaac E Hall, Marie-Louise Landry and Maricar F Malinis
Funding Agency and Grant Number
Corresponding Author	Marwan M Azar, MD, Department of Pathology, Section of Microbiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02145, United States. mmazar@mgh.harvard.edu
Key Words	BK virus; Renal transplant; Screening; PyVAN; Prevention; Graft loss
Core Tip	The authors describe results of a retrospective study of 319 renal transplant recipients who underwent reduction of immunosuppression for BK viremia at a BK viral of ≥ 3-log copies/mL. Instituting early reduction of immunosuppression in the absence of adjunctive antivirals was effective in reducing the incidence of graft loss due to Polyoma-virus associated nephropathy (PyVAN) without a reciprocal increase in acute rejection. Our study also emphasizes that efforts to implement universal BK virus polymerase chain reaction assay standards recently developed by the World Health Organization are key in establishing a preventative strategy for PyVAN that is widely applicable and highly effective.
Publish Date	2017-10-23 07:26
Citation	Azar MM, Assi R, Valika AK, Banach DB, Hall IE, Landry ML, Malinis MF. Graft loss among renal-transplant recipients with early reduction of immunosuppression for BK viremia. World J Transplant 2017; 7(5): 269-275
URL	http://www.wjgnet.com/2220-3230/full/v7/i5/269.htm
DOI	http://dx.doi.org/10.5500/wjt.v7.i5.269

Full Article (PDF)	WJT-7-269.pdf
Full Article (Word)	WJT-7-269.doc
Manuscript File	33503-Review.docx
Answering Reviewers	33503-Answering reviewers.pdf
Audio Core Tip	33503-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33503-Conflict-of-interest statement.pdf
Copyright License Agreement	33503-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	33503_Baishideng Publishing COI 20170602.pdf
Institutional Review Board Approval Form or Document	33503-Institutional review board statement.pdf
Peer-review Report	33503-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33503-Journal editor-in-chief review report.pdf
Journal Editor-in-Chief Review Report	35503-Scientific misconduct check.pdf
Scientific Editor Work List	33503-Scientific editor work list.pdf