Publication Name	World Journal of Gastroenterology
Manuscript ID	33528
Country	Norway

Received	2017-02-14 08:27
Peer-Review Started	2017-02-16 20:08
To Make the First Decision	2017-04-05 17:18
Return for Revision	2017-04-06 09:49
Revised	2017-04-15 23:29
Second Decision	2017-07-06 07:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-12 06:04
Articles in Press	2017-07-12 06:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-19 02:38
Publish the Manuscript Online	2017-07-28 08:16

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Gastrointestinal neuroendocrine peptides/amines in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Magdy El-Salhy, Tefera Solomon, Trygve Hausken, Odd Helge Gilja and Jan Gunnar Hatlebakk
Funding Agency and Grant Number
Corresponding Author	Magdy El-Salhy, Professor, Division of Gastroenterology, Department of Medicine, Stord Hospital, Box 4000, Stord 5409, Norway. magdy.el-salhy@helse-fonna.no
Key Words	Enteric nervous system; Enteroendocrine cells; Immune cells; Inflammatory bowel disease; Musashi-1; Neurogenin 3; Stem cells
Core Tip	Approximately 80% of the body immune cells (IC) are localized in the gastrointestinal (GI) tract close to the GI neuroendocrine regulatory system (NES). Many IC express GI neuroendocrine peptides/amines (NEPA) and possess receptors to several NEPA. Several GI NEPA are abnormal during active inflammatory bowel disease (IBD) in both patients and animal models of IBD. The changes in the GI NEPA are correlated with those of the IC during the inflammatory process. Studying the interactions between the GI NES and the immune system in IBD may improve our understanding of the pathophysiology of IBD and provide us with new tools for treatment.
Publish Date	2017-07-28 08:16
Citation	El-Salhy M, Solomon T, Hausken T, Gilja OH, Hatlebakk JG. Gastrointestinal neuroendocrine peptides/amines in inflammatory bowel disease. World J Gastroenterol 2017; 23(28): 5068-5085
URL	http://www.wjgnet.com/1007-9327/full/v23/i28/5068.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i28.5068

Full Article (PDF)	WJG-23-5068.pdf
Full Article (Word)	WJG-23-5068.doc
Manuscript File	33528-Review.doc
Answering Reviewers	33528-Answering reviewers.pdf
Audio Core Tip	33528-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	33528-Conflict-of-interest statement.pdf
Copyright License Agreement	33528-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	33528-Language certificate.pdf
Supplementary Material	33528_Permission.pdf
Peer-review Report	33528-Peer-review(s).pdf
Scientific Misconduct Check	33528-Scientific misconduct check.pdf
Scientific Editor Work List	33528-Scientific editor work list.pdf