Publication Name	World Journal of Gastroenterology
Manuscript ID	33581
Country	Japan

Received	2017-02-20 10:52
Peer-Review Started	2017-02-20 17:53
To Make the First Decision	2017-03-16 13:44
Return for Revision	2017-03-20 09:18
Revised	2017-03-22 20:44
Second Decision	2017-04-27 17:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-05-04 18:25
Articles in Press	2017-05-04 18:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-24 12:21
Publish the Manuscript Online	2017-06-07 07:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Spontaneous regression of hepatocellular carcinoma: A mini-review
Manuscript Source	Invited Manuscript
All Author List	Akira Sakamaki, Kenya Kamimura, Satoshi Abe, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa and Shuji Terai
Funding Agency and Grant Number
Corresponding Author	Kenya Kamimura, MD, PhD, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachido-ri, Chuo-ku, Niigata 951-8510, Japan. kenya-k@med.niigata-u.ac.jp
Key Words	Spontaneous regression; Hepatocellular carcinoma; Immunological reaction; Immunotherapy; Hypoxia
Core Tip	Spontaneous tumor regression of hepato­cellular carcinoma (HCC) have been reported in several reports although rare. The analyses of the mechanisms underlying this phenomenon is the potential target for the novel therapeutic methods for HCC. For this purpose, we have carefully reviewed 24 cases of spontaneously regressed HCC including cases published in recent 5-years and our case. The minute clinical information and clinical courses are reviewed and summarized. Based on the information, hypoxia and/or systemic inflammation are involved in all cases for which the information regarding the proposed mechanism is available. An accumulation of additional cases and the analysis of mechanism underlying the spontaneous regression of HCC could lead to the development of new therapeutic strategy for HCC.
Publish Date	2017-06-07 07:22
Citation	Sakamaki A, Kamimura K, Abe S, Tsuchiya A, Takamura M, Kawai H, Yamagiwa S, Terai S. Spontaneous regression of hepatocellular carcinoma: A mini-review. World J Gastroenterol 2017; 23(21): 3797-3804
URL	http://www.wjgnet.com/1007-9327/full/v23/i21/3797.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i21.3797

Full Article (PDF)	WJG-23-3797.pdf
Full Article (Word)	WJG-23-3797.doc
Manuscript File	33581-Review.docx
Answering Reviewers	33581-Answering reviewers.pdf
Audio Core Tip	33581-Audio core tip.wma
Conflict-of-Interest Disclosure Form	33581-Conflict-of-interest statement.pdf
Copyright License Agreement	33581-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	33581-Language certificate.pdf
Peer-review Report	33581-Peer-review(s).pdf
Scientific Misconduct Check	33581-Scientific misconduct check.pdf
Scientific Editor Work List	33581-Scientific editor work list.pdf