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6/7/2017 7:22:42 AM | Browse: 48 | Download: 70
Publication Name World Journal of Gastroenterology
Manuscript ID 33581
Country of Manuscript Source Japan
Received
2017-02-20 10:52
Peer-Review Started
2017-02-20 17:53
To Make the First Decision
2017-03-16 13:44
Return for Revision
2017-03-20 09:18
Revised
2017-03-22 20:44
Second Decision
2017-04-27 17:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-04 18:25
Articles In Press
2017-05-04 18:25
Publication Fee Transferred
Edit the Manuscript by Languag Editor
Typeset the Manuscript
2017-05-24 12:21
Publish the Manuscript Online
2017-06-07 07:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Spontaneous regression of hepatocellular carcinoma: A mini-review
Manuscript Source Invited Manuscript
All Author List Akira Sakamaki, Kenya Kamimura, Satoshi Abe, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa and Shuji Terai
Funding Agency and Grant Number
Correspondence To Kenya Kamimura, MD, PhD, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachido-ri, Chuo-ku, Niigata 951-8510, Japan. kenya-k@med.niigata-u.ac.jp
Keywords Spontaneous regression; Hepatocellular carcinoma; Immunological reaction; Immunotherapy; Hypoxia
Core Tip Spontaneous tumor regression of hepato­cellular carcinoma (HCC) have been reported in several reports although rare. The analyses of the mechanisms underlying this phenomenon is the potential target for the novel therapeutic methods for HCC. For this purpose, we have carefully reviewed 24 cases of spontaneously regressed HCC including cases published in recent 5-years and our case. The minute clinical information and clinical courses are reviewed and summarized. Based on the information, hypoxia and/or systemic inflammation are involved in all cases for which the information regarding the proposed mechanism is available. An accumulation of additional cases and the analysis of mechanism underlying the spontaneous regression of HCC could lead to the development of new therapeutic strategy for HCC.
Publish Date 2017-06-07 07:22
Citation Sakamaki A, Kamimura K, Abe S, Tsuchiya A, Takamura M, Kawai H, Yamagiwa S, Terai S. Spontaneous regression of hepatocellular carcinoma: A mini-review. World J Gastroenterol 2017; 23(21): 3797-3804
Url http://www.wjgnet.com/1007-9327/full/v23/i21/3797.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i21.3797
Full Article (PDF) WJG-23-3797.pdf
Full Article (Word) WJG-23-3797.doc
Revised Manuscript 33581-Review.docx
Peer-review Report 33581-Peer-review(s).pdf
Answering Reviewers 33581-Answering reviewers.pdf
Scientific Misconduct Check 33581-Scientific misconduct check.pdf
Scientific Editor Work List 33581-Scientific editor work list.pdf
Audio 33581-Audio core tip.wma
Conflict-of-Interest Statement 33581-Conflict-of-interest statement.pdf
Copyright Assignment 33581-Copyright assignment.pdf
Non-Native Speakers of English 33581-Language certificate.pdf