Publication Name	World Journal of Cardiology
Manuscript ID	33592
Country	United States

Received	2017-02-20 10:28
Peer-Review Started	2017-02-20 18:34
To Make the First Decision	2017-03-27 08:29
Return for Revision	2017-03-29 12:07
Revised	2017-05-10 11:17
Second Decision	2017-05-15 03:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-05-24 00:51
Articles in Press	2017-05-24 00:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-09-13 06:30
Publish the Manuscript Online	2017-09-25 02:01

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Takotsubo cardiomyopathy: Pathophysiology and role of cardiac biomarkers in differential diagnosis
Manuscript Source	Invited Manuscript
All Author List	Prabhakaran Gopalakrishnan, Ramsha Zaidi and Muhammad Rizwan Sardar
Funding Agency and Grant Number
Corresponding Author	Muhammad Rizwan Sardar, MD, Division of Cardiology, Department of Medicine, Aultman Hospital, 2600 6th St SW, Canton, OH 44710, United States. m.rizwan.sardar@aultman.com
Key Words	Takotsubo cardiomyopathy; Natriuretic peptide; Brain natriuretic peptide; N-terminal-pro brain natriuretic peptide; Troponin; Cardiac biomarkers; Acute myocardial infarction
Core Tip	Takotsubo cardiomyopathy (TC) characterized by reversible ventricular dysfunction is frequently mistaken for acute anterior wall myocardial infarction often leading to avoidable cardiac catheterizations. While several clinical clues differentiate TC and acute coronary syndrome (ACS), a clinical diagnosis still remains elusive. We review the pathophysiology and diagnosis of TC with a focus on role of cardiac biomarkers [natriuretic peptides - brain natriuretic peptide (BNP) and NT-proBNP and cardiac myonecrosis markers - Troponin, CKMB and Myoglobin]. We have done a review of several studies looking at diagnostic utility of cardiac biomarkers in differentiating TC and ACS.
Publish Date	2017-09-25 02:01
Citation	Gopalakrishnan P, Zaidi R, Sardar MR. Takotsubo cardiomyopathy: Pathophysiology and role of cardiac biomarkers in differential diagnosis. World J Cardiol 2017; 9(9): 723-730
URL	http://www.wjgnet.com/1949-8462/full/v9/i9/723.htm
DOI	http://dx.doi.org/10.4330/wjc.v9.i9.723

Full Article (PDF)	WJC-9-723.pdf
Full Article (Word)	WJC-9-723.doc
Manuscript File	33592-Review.docx
Answering Reviewers	33592-Answering reviewers.pdf
Audio Core Tip	33592-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33592-Conflict-of-interest statement.pdf
Copyright License Agreement	33592-Copyright assignment.pdf
Peer-review Report	33592-Peer-review(s).pdf
Scientific Misconduct Check	33592-Scientific misconduct check.pdf
Scientific Editor Work List	33592-Scientific editor work list.pdf