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9/15/2017 5:43:48 AM | Browse: 346 | Download: 222
Publication Name World Journal of Hepatology
Manuscript ID 33606
Country of Manuscript Source Ireland
Received
2017-02-20 09:51
Peer-Review Started
2017-02-20 18:19
To Make the First Decision
2017-03-28 17:39
Return for Revision
2017-04-01 16:59
Revised
2017-04-20 05:18
Second Decision
2017-06-29 08:35
Accepted by Journal Editor-in-Chief
2017-06-29 10:23
Accepted by Company Editor-in-Chief
2017-07-10 02:46
Articles in Press
2017-07-10 02:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-12 08:35
Publish the Manuscript Online
2017-09-15 05:43
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Authors 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Risk of liver disease in methotrexate treated patients
Manuscript Source Invited Manuscript
All Author List Richard Conway and John J Carey
Funding Agency and Grant Number
Corresponding author Richard Conway, Centre for Arthritis and Rheumatic Diseases, St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland. drrichardconway@gmail.com
Keywords Liver disease; Transaminases; Fibrosis; Cirrhosis; Methotrexate; Hepatic
Core Tip Methotrexate is a highly effective treatment for many diseases. In rheumatoid arthritis it controls symptoms, prevents damage, and reduces mortality. The risks of methotrexate use are often over-estimated. Methotrexate may result in asymptomatic transaminase elevations. Historically methotrexate has been in­frequently associated with more severe liver adverse events. With modern monitoring and management of liver blood tests serious liver related adverse events related to methotrexate use appear to be avoidable.
Publish Date 2017-09-15 05:43
Citation Conway R, Carey JJ. Risk of liver disease in methotrexate treated patients. World J Hepatol 2017; 9(26): 1092-1100
Url http://www.wjgnet.com/1948-5182/full/v9/i26/1092.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i26.1092
Full Article (PDF) WJH-9-1092.pdf
Full Article (Word) WJH-9-1092.doc
Manuscript File 33606-Review.docx
Answering Reviewers 33606-Answering reviewers.pdf
Audio Core Tip 33606-Audio core tip.mp3
Biostatistics Review Certificate Biostatistics_Statement_20170220045614.docx
Clinical Trial Registration Statement DeclarationOf_HelsinkiConformation_Statement_20170220045239.docx
Conflict-of-Interest Disclosure Form 33606-Conflict-of-interest statement.pdf
Copyright License Agreement 33606-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20170220045146.docx
Institutional Animal Care and Use Committee Approval Form or Document Institutional_Animal_Care_and_Use_Committee_Statement_20170220045333.docx
Institutional Review Board Approval Form or Document Institutional_Review_Board_Statement_20170220045042.docx
Peer-review Report 33606-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 33606-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 33606-Scientific misconduct check.pdf
Scientific Editor Work List 33606-Scientific editor work list.pdf