ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Medicine, Research & Experimental |
Manuscript Type |
Basic Study |
Article Title |
Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Zhi-Yuan Li, Yan Huang, Yan-Ting Yang, Dan Zhang, Yan Zhao, Jue Hong, Jie Liu, Li-Jie Wu, Cui-Hong Zhang, Huan-Gan Wu, Ji Zhang and Xiao-Peng Ma |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81273843 |
National Natural Science Foundation of China |
81674073 |
National Key Basic Research Program of China (973 Program) |
2015CB554501 |
Project of Shanghai Municipal Commission of Health and Family Planning |
20144Y0153 |
Project of Shanghai Municipal Commission of Health and Family Planning |
017BR047 |
|
Corresponding Author |
Xiao-Peng Ma, PhD, Research Fellow, Shanghai Research Institute of Acupuncture and Meridian, No. 650 South Wanping Road, Xuhui District, Shanghai 200030, China. pengpengma@163.com |
Key Words |
Herb-partitioned moxibustion; Chronic inflammatory visceral pain; Pain behavior; Analgesia; MEK; Extracellular signal-regulated kinase; cAMP response element binding protein; Signaling pathway |
Core Tip |
chronic inflammatory visceral pain (CIVP) (abdominal pain) is one of the major symptoms of inflammatory bowel disease. Herb-partitioned moxibustion (HPM) at bilateral Tianshu (ST25) and Qihai (CV6) acupoints was effective in enhancing the pain threshold and easing pain in CIVP rats. Levels of phosphorylated protein and mRNA expression of mitogen-activated extracellular signal-regulated kinase 1, extracellular signal-regulated kinase and cAMP response element binding protein were abnormally increased in the spinal cord of CIVP rats. HPM effectively down-regulated the abnormally increased expression, which is possibly one of the analgesic mechanisms of HPM. |
Publish Date |
2017-09-14 03:13 |
Citation |
Li ZY, Huang Y, Yang YT, Zhang D, Zhao Y, Hong J, Liu J, Wu LJ, Zhang CH, Wu HG, Zhang J, Ma XP. Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats. World J Gastroenterol 2017; 23(34): 6220-6230 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i34/6220.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i34.6220 |