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9/21/2017 7:51:53 AM | Browse: 809 | Download: 1285
Publication Name World Journal of Gastroenterology
Manuscript ID 33656
Country/Territory China
Received
2017-02-23 08:49
Peer-Review Started
2017-02-24 17:19
To Make the First Decision
2017-06-05 00:29
Return for Revision
2017-06-10 11:54
Revised
2017-06-21 17:26
Second Decision
2017-08-07 05:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-08-15 15:23
Articles in Press
2017-08-15 15:23
Publication Fee Transferred
2017-08-18 04:48
Edit the Manuscript by Language Editor
2017-08-31 03:26
Typeset the Manuscript
2017-09-09 08:00
Publish the Manuscript Online
2017-09-21 07:51
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Effects of aspirin and enoxaparin in a rat model of liver fibrosis
Manuscript Source Unsolicited Manuscript
All Author List Chen-Jie Li, Zhi-Hui Yang, Xiao-Liu Shi and De-Liang Liu
Funding Agency and Grant Number
Corresponding Author Chen-Jie Li, MD, PhD, Department of Gastroenterology, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China. chenjielimao@126.com
Key Words Aspirin; Enoxaparin; Thioacetamide; Liver fibrosis; Rat
Core Tip Several evidences show that intrahepatic thrombosis is associated with liver fibrosis.Based on these observations, we hypothesize that routine use of antithrombotic drugs may prevent liver fibrosis. In our study, we successfully established a rat model of liver fibrosis after 8 weeks and successfully established a rat model of liver cirrhosis after 12 weeks through thioacetamide - induced method. Our study clearly shows that aspirin and enoxaparin can reduce liver fibrosis in rats. However, reporting the results in humans is more complicated,because we should consider other aspects as the renal function.
Publish Date 2017-09-21 07:51
Citation Li CJ, Yang ZH, Shi XL, Liu DL. Effects of aspirin and enoxaparin in a rat model of liver fibrosis. World J Gastroenterol 2017; 23(35): 6412-6419
URL http://www.wjgnet.com/1007-9327/full/v23/i35/6412.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i35.6412
Full Article (PDF) WJG-23-6412.pdf
Full Article (Word) WJG-23-6412.doc
Manuscript File 33656-Review.doc
Answering Reviewers 33656-Answering reviewers.pdf
Audio Core Tip 33656-Audio core tip.mp3
Biostatistics Review Certificate 33656-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 33656-Conflict-of-interest statement.pdf
Copyright License Agreement 33656-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 33656-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 33656-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 33656-Language certificate.pdf
Peer-review Report 33656-Peer-review(s).pdf
Scientific Misconduct Check 33656-Scientific misconduct check.pdf
Scientific Editor Work List 33656-Scientific editor work list.pdf