Publication Name	World Journal of Gastroenterology
Manuscript ID	33656
Country	China

Received	2017-02-23 08:49
Peer-Review Started	2017-02-24 17:19
To Make the First Decision	2017-06-05 00:29
Return for Revision	2017-06-10 11:54
Revised	2017-06-21 17:26
Second Decision	2017-08-07 05:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-08-15 15:23
Articles in Press	2017-08-15 15:23
Publication Fee Transferred	2017-08-18 04:48
Edit the Manuscript by Language Editor	2017-08-31 03:26
Typeset the Manuscript	2017-09-09 08:00
Publish the Manuscript Online	2017-09-21 07:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effects of aspirin and enoxaparin in a rat model of liver fibrosis
Manuscript Source	Unsolicited Manuscript
All Author List	Chen-Jie Li, Zhi-Hui Yang, Xiao-Liu Shi and De-Liang Liu
Funding Agency and Grant Number
Corresponding Author	Chen-Jie Li, MD, PhD, Department of Gastroenterology, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China. chenjielimao@126.com
Key Words	Aspirin; Enoxaparin; Thioacetamide; Liver fibrosis; Rat
Core Tip	Several evidences show that intrahepatic thrombosis is associated with liver fibrosis.Based on these observations, we hypothesize that routine use of antithrombotic drugs may prevent liver fibrosis. In our study, we successfully established a rat model of liver fibrosis after 8 weeks and successfully established a rat model of liver cirrhosis after 12 weeks through thioacetamide - induced method. Our study clearly shows that aspirin and enoxaparin can reduce liver fibrosis in rats. However, reporting the results in humans is more complicated,because we should consider other aspects as the renal function.
Publish Date	2017-09-21 07:51
Citation	Li CJ, Yang ZH, Shi XL, Liu DL. Effects of aspirin and enoxaparin in a rat model of liver fibrosis. World J Gastroenterol 2017; 23(35): 6412-6419
URL	http://www.wjgnet.com/1007-9327/full/v23/i35/6412.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i35.6412

Full Article (PDF)	WJG-23-6412.pdf
Full Article (Word)	WJG-23-6412.doc
Manuscript File	33656-Review.doc
Answering Reviewers	33656-Answering reviewers.pdf
Audio Core Tip	33656-Audio core tip.mp3
Biostatistics Review Certificate	33656-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	33656-Conflict-of-interest statement.pdf
Copyright License Agreement	33656-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	33656-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	33656-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	33656-Language certificate.pdf
Peer-review Report	33656-Peer-review(s).pdf
Scientific Misconduct Check	33656-Scientific misconduct check.pdf
Scientific Editor Work List	33656-Scientific editor work list.pdf