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Articles Published Processes
12/12/2017 8:34:13 AM | Browse: 1171 | Download: 2067
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Received |
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2017-02-24 09:12 |
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Peer-Review Started |
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2017-02-24 17:40 |
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To Make the First Decision |
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2017-04-21 10:35 |
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Return for Revision |
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2017-04-28 17:14 |
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Revised |
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2017-09-15 08:04 |
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Second Decision |
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2017-11-01 06:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-01 21:17 |
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Articles in Press |
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2017-11-01 21:17 |
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Publication Fee Transferred |
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2017-11-10 00:42 |
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Edit the Manuscript by Language Editor |
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2017-11-22 14:08 |
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Typeset the Manuscript |
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2017-12-05 09:05 |
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Publish the Manuscript Online |
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2017-12-12 08:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin Wang, Tao Ye, Wen-Jie Chen, You Lv, Zong Hao, Jun Chen, Jia-Ying Zhao, Hui-Peng Wang and Yuan-Kun Cai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Minhang District of Shanghai |
2012MHZ001 |
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| Corresponding Author |
Yuan-Kun Cai, MSc, Associate Professor, Chief Doctor, Surgeon of General Surgery, The Department of General Surgery, The 5th People’s Hospital of Shanghai, Fudan University, 801 Heqing Road, Shanghai 200240, China. yuankun@medmail.com.cn |
| Key Words |
Epigallocatechin gallate; Gut microbiota; Colorectal cancer; High throughput sequencing; Chemoprevention; Animal experiment |
| Core Tip |
Our study revealed the protective role of Epigallocatechin gallate (EGCG) on colorectal carcinogenesis and structural changes of intestinal flora in animal model of colorectal cancer. EGCG was detected for its roles through azoxymethane/dextran sulfate sodium induced tumor (aberrant crypt foci) formation. The microbial population was compared among groups at different developmental stages by pyrosequencing of V4 regions of 16S rRNA genes. Results suggested that intestinal flora imbalance might be a potential mechanism for the prevention of malignant transformation by the green tea extract EGCG, significant for the diagnosis, treatment, prognosis and prevention of colorectal cancer. |
| Publish Date |
2017-12-12 08:34 |
| Citation |
Wang X, Ye T, Chen WJ, Lv Y, Hao Z, Chen J, Zhao JY, Wang HP, Cai YK. Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice. World J Gastroenterol 2017; 23(46): 8128-8139 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i46/8128.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i46.8128 |
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