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12/12/2017 8:34:13 AM | Browse: 1012 | Download: 1558
Publication Name World Journal of Gastroenterology
Manuscript ID 33667
Country/Territory China
Received
2017-02-24 09:12
Peer-Review Started
2017-02-24 17:40
To Make the First Decision
2017-04-21 10:35
Return for Revision
2017-04-28 17:14
Revised
2017-09-15 08:04
Second Decision
2017-11-01 06:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-01 21:17
Articles in Press
2017-11-01 21:17
Publication Fee Transferred
2017-11-10 00:42
Edit the Manuscript by Language Editor
2017-11-22 14:08
Typeset the Manuscript
2017-12-05 09:05
Publish the Manuscript Online
2017-12-12 08:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice
Manuscript Source Unsolicited Manuscript
All Author List Xin Wang, Tao Ye, Wen-Jie Chen, You Lv, Zong Hao, Jun Chen, Jia-Ying Zhao, Hui-Peng Wang and Yuan-Kun Cai
ORCID
Author(s) ORCID Number
Hui-Peng Wang http://orcid.org/0000-0001-6575-2340
Yuan-Kun Cai http://orcid.org/0000-0001-9735-200X
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Minhang District of Shanghai 2012MHZ001
Corresponding Author Yuan-Kun Cai, MSc, Associate Professor, Chief Doctor, Surgeon of General Surgery, The Department of General Surgery, The 5th People’s Hospital of Shanghai, Fudan University, 801 Heqing Road, Shanghai 200240, China. yuankun@medmail.com.cn
Key Words Epigallocatechin gallate; Gut microbiota; Colorectal cancer; High throughput sequencing; Chemoprevention; Animal experiment
Core Tip Our study revealed the protective role of Epigallocatechin gallate (EGCG) on colorectal carcinogenesis and structural changes of intestinal flora in animal model of colorectal cancer. EGCG was detected for its roles through azoxymethane/dextran sulfate sodium induced tumor (aberrant crypt foci) formation. The microbial population was compared among groups at different developmental stages by pyrosequencing of V4 regions of 16S rRNA genes. Results suggested that intestinal flora imbalance might be a potential mechanism for the prevention of malignant transformation by the green tea extract EGCG, significant for the diagnosis, treatment, prognosis and prevention of colorectal cancer.
Publish Date 2017-12-12 08:34
Citation Wang X, Ye T, Chen WJ, Lv Y, Hao Z, Chen J, Zhao JY, Wang HP, Cai YK. Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice. World J Gastroenterol 2017; 23(46): 8128-8139
URL http://www.wjgnet.com/1007-9327/full/v23/i46/8128.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i46.8128
Full Article (PDF) WJG-23-8128.pdf
Full Article (Word) WJG-23-8128.doc
Manuscript File 33667-Review.doc
Answering Reviewers 33667-Answering reviewers.pdf
Audio Core Tip 33667-Audio core tip.mp3
Biostatistics Review Certificate 33667-Biostatistics statement.PDF
Conflict-of-Interest Disclosure Form 33667-Conflict-of-interest statement.PDF
Copyright License Agreement 33667-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 33667-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 33667-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 33667-Institutional-Review-Board-Statement-revision.jpg
Non-Native Speakers of English Editing Certificate 33667-Language certificate.pdf
Peer-review Report 33667-Peer-review(s).pdf
Scientific Misconduct Check 33667-Scientific misconduct check.pdf
Scientific Editor Work List 33667-Scientific editor work list.pdf