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8/14/2017 8:57:06 AM | Browse: 803 | Download: 891
Publication Name World Journal of Gastroenterology
Manuscript ID 33732
Country/Territory Belgium
Received
2017-02-28 09:46
Peer-Review Started
2017-03-02 15:07
To Make the First Decision
2017-04-05 17:17
Return for Revision
2017-04-06 13:50
Revised
2017-05-16 13:03
Second Decision
2017-05-27 01:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-06-01 08:52
Articles in Press
2017-06-01 08:52
Publication Fee Transferred
2017-06-07 09:16
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-02 07:49
Publish the Manuscript Online
2017-08-14 04:00
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease
Manuscript Source Unsolicited Manuscript
All Author List Frederik Temmerman, Feng Chen, Louis Libbrecht, Ingrid Vander Elst, Petra Windmolders, Yuanbo Feng, Yicheng Ni, Humbert De Smedt, Frederik Nevens and Jos van Pelt
Funding Agency and Grant Number
Corresponding Author Jos van Pelt, Professor, Laboratory of Hepatology, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Leuven, Geb. Onderwijs and Navorsing 1, 7e verd, bus 703, Herestraat 49, Leuven B 3000, Belgium. jos.vanpelt@kuleuven.be
Key Words Fibrocystic liver disease; mTOR inhibitor; somatostatin analogue; liver volume measurement; Magnetic resonance imaging
Core Tip The continuous increase of liver cysts volume in polycystic-liver-disease (PCLD) leads to extensive hepatomegaly and portal hypertension, an indication for liver transplantation. The effect of mTOR-inhibition on liver volume (LV) in PCLD is unclear. We developed an accurate, non-invasive, MRI-based method to determine LV in a PCLD rat model. When treatment is started at the moment of extensive hepatomegaly (as in humans), the mTOR inhibitor everolimus halt disease progression and also of the development of fibrosis in this model. We speculate that everolimus, given after kidney transplantation in patients with PCLD, can prevent the development of symptomatic hepatomegaly.
Publish Date 2017-08-14 04:00
Citation Temmerman F, Chen F, Libbrecht L, Vander Elst I, Windmolders P, Feng Y, Ni Y, De Smedt H, Nevens F, van Pelt J. Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease. World J Gastroenterol 2017; 23(30): 5499-5507
URL http://www.wjgnet.com/1007-9327/full/v23/i30/5499.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i30.5499
Full Article (PDF) WJG-23-5499.pdf
Full Article (Word) WJG-23-5499.doc
Manuscript File 33732-Review.docx
Answering Reviewers 33732-Answering reviewers.pdf
Audio Core Tip 33732-Audio core tip.mp3
Biostatistics Review Certificate 33732-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 33732-Conflict-of-interest statement.pdf
Copyright License Agreement 33732-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 33732-Institutional animal care and use committee statement.pdf
Supplementary Material 33732_Author listWJG33732.docx
Peer-review Report 33732-Peer-review(s).pdf
Scientific Misconduct Check 33732-Scientific misconduct check.pdf
Scientific Editor Work List 33732-Scientific editor work list.pdf