Publication Name	World Journal of Diabetes
Manuscript ID	33755
Country	Pakistan

Received	2017-03-01 09:15
Peer-Review Started	2017-03-02 16:05
To Make the First Decision	2017-03-27 11:26
Return for Revision	2017-03-28 15:59
Revised	2017-04-03 09:32
Second Decision	2017-04-14 11:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-04-24 10:15
Articles in Press	2017-04-24 10:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-04 07:32
Publish the Manuscript Online	2017-06-15 02:07

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study
Manuscript Source	Invited Manuscript
All Author List	Syeda Sadia Fatima, Zehra Jamil, Syed Hani Abidi, Daniyal Nadeem, Zara Bashir and Ahmed Ansari
Funding Agency and Grant Number
Corresponding Author	Dr. Zehra Jamil, Senior Instructor, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan, Stadium Road, Karachi 74800, Pakistan. zehra.jamil@aku.edu
Key Words	Metabolic syndrome; Interleukin-18; Polymor­phism; Obesity; Body fat; High density lipoprotein; Low density lipoprotein; Insulin
Core Tip	Interleukin-18 (IL-18) gene polymorphisms may influence the expression of its levels. This in turn increases the risk of metabolic syndrome (MetS). Therefore, we aimed to assess the circulatory levels of IL-18 and determine whether the presence of IL-18 promoter polymorphism influences MetS phenotypes. Subjects with AA genotype had a higher body fat, insulin resistance, tumor necrosis factor α and IL-18 levels when compared with subjects with AC (heterozygous) or CC (wild type) genotypes. This preliminary data suggests that IL-18 polymorphism affects IL-18 levels that might cause low grade inflammation. All these increase the susceptibility to develop MetS. Further studies are required to validate our findings.
Publish Date	2017-06-15 02:07
Citation	Fatima SS, Jamil Z, Abidi SH, Nadeem D, Bashir Z, Ansari A. Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study. World J Diabetes 2017; 8(6): 304-310
URL	http://www.wjgnet.com/1948-9358/full/v8/i6/304.htm
DOI	http://dx.doi.org/10.4239/wjd.v8.i6.304

Full Article (PDF)	WJD-8-304.pdf
Full Article (Word)	WJD-8-304.doc
Manuscript File	33755-Review.doc
Answering Reviewers	33755-Answering reviewers.pdf
Audio Core Tip	33755-Audio core tip.m4a
Biostatistics Review Certificate	33755-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	33755-Conflict-of-interest statement.pdf
Copyright License Agreement	33755-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	33755-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	33755-Institutional review board statement.pdf
Peer-review Report	33755-Peer-review(s).pdf
Scientific Misconduct Check	33755-Scientific misconduct check.pdf
Scientific Editor Work List	33755-Scientific editor work list.pdf