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6/15/2017 2:07:09 AM | Browse: 321 | Download: 517
Publication Name World Journal of Diabetes
Manuscript ID 33755
Country of Manuscript Source Pakistan
Received
2017-03-01 09:15
Peer-Review Started
2017-03-02 16:05
To Make the First Decision
2017-03-27 11:26
Return for Revision
2017-03-28 15:59
Revised
2017-04-03 09:32
Second Decision
2017-04-14 11:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-04-24 10:15
Articles in Press
2017-04-24 10:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-06-04 07:32
Publish the Manuscript Online
2017-06-15 02:07
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Endocrinology and Metabolism
Manuscript Type Observational Study
Article Title Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study
Manuscript Source Invited Manuscript
All Author List Syeda Sadia Fatima, Zehra Jamil, Syed Hani Abidi, Daniyal Nadeem, Zara Bashir and Ahmed Ansari
Funding Agency and Grant Number
Corresponding author Dr. Zehra Jamil, Senior Instructor, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan, Stadium Road, Karachi 74800, Pakistan. zehra.jamil@aku.edu
Keywords Metabolic syndrome; Interleukin-18; Polymor­phism; Obesity; Body fat; High density lipoprotein; Low density lipoprotein; Insulin
Core Tip Interleukin-18 (IL-18) gene polymorphisms may influence the expression of its levels. This in turn increases the risk of metabolic syndrome (MetS). Therefore, we aimed to assess the circulatory levels of IL-18 and determine whether the presence of IL-18 promoter polymorphism influences MetS phenotypes. Subjects with AA genotype had a higher body fat, insulin resistance, tumor necrosis factor α and IL-18 levels when compared with subjects with AC (heterozygous) or CC (wild type) genotypes. This preliminary data suggests that IL-18 polymorphism affects IL-18 levels that might cause low grade inflammation. All these increase the susceptibility to develop MetS. Further studies are required to validate our findings.
Publish Date 2017-06-15 02:07
Citation Fatima SS, Jamil Z, Abidi SH, Nadeem D, Bashir Z, Ansari A. Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study. World J Diabetes 2017; 8(6): 304-310
Url http://www.wjgnet.com/1948-9358/full/v8/i6/304.htm
DOI http://dx.doi.org/10.4239/wjd.v8.i6.304
Full Article (PDF) WJD-8-304.pdf
Full Article (Word) WJD-8-304.doc
Manuscript File 33755-Review.doc
Answering Reviewers 33755-Answering reviewers.pdf
Audio Core Tip 33755-Audio core tip.m4a
Biostatistics Review Certificate 33755-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 33755-Conflict-of-interest statement.pdf
Copyright License Agreement 33755-Copyright assignment.pdf
Data Sharing Statement 33755-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) 33755-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 33755-Institutional review board statement.pdf
Scientific Research Process 33755-Scientific research process.pdf
Peer-review Report 33755-Peer-review(s).pdf
Scientific Misconduct Check 33755-Scientific misconduct check.pdf
Scientific Editor Work List 33755-Scientific editor work list.pdf