Publication Name	World Journal of Gastroenterology
Manuscript ID	33759
Country	Singapore

Received	2017-03-01 09:08
Peer-Review Started	2017-03-02 09:08
To Make the First Decision	2017-04-21 10:35
Return for Revision	2017-04-28 17:12
Revised	2017-05-11 16:59
Second Decision	2017-06-16 13:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-06-19 09:41
Articles in Press	2017-06-19 09:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-06-23 20:37
Typeset the Manuscript	2017-07-14 04:19
Publish the Manuscript Online	2017-07-20 10:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Current research and treatment for gastrointestinal stromal tumors
Manuscript Source	Invited Manuscript
All Author List	Kheng Tian Lim and Kok Yang Tan
Funding Agency and Grant Number
Corresponding Author	Kheng Tian Lim, Department of Surgery, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore 768828, Singapore. lim.kheng.tian@alexandrahealth.com.sg
Key Words	Gastrointestinal stromal tumors; KIT gene; Platelet-derived growth factor receptor alpha gene; BRAF gene; Succinate dehydrogenase gene; CD117; Tyrosine kinase inhibitor; Molecular targeted therapy
Core Tip	Research in the histogenesis of gastrointestinal stromal tumors (GISTs) identified gene mutations in KIT, platelet-derived growth factor receptor alpha and BRAF. The discovery of tyrosine kinase inhibitors (TKIs) has allowed targeted therapy in metastatic and high-risk resected GISTs. However, the emergence of TKI-resistant GISTs has raised some important treatment issues. Newer TKIs and alternative targeted therapy within the domain of BRAF and the mitogen-activated protein kinase signaling pathway, heat shock protein 90 and succinate dehydrogenase inhibition are being investigated and appear promising. Many clinical trials have been undertaken and are still ongoing to define the best molecular targeted therapy for GISTs. The European, American and Asian guidelines on GISTs provide useful resources for specialists dealing with these interesting tumors.
Publish Date	2017-07-20 10:12
Citation	Lim KT, Tan KY. Current research and treatment for gastrointestinal stromal tumors. World J Gastroenterol 2017; 23(27): 4856-4866
URL	http://www.wjgnet.com/1007-9327/full/v23/i27/4856.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i27.4856

Full Article (PDF)	WJG-23-4856.pdf
Full Article (Word)	WJG-23-4856.doc
Manuscript File	33759-Review.docx
Answering Reviewers	33759-Answering reviewers.pdf
Audio Core Tip	33759-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33759-Conflict-of-interest statement.pdf
Copyright License Agreement	33759-Copyright assignment.pdf
Peer-review Report	33759-Peer-review(s).pdf
Scientific Misconduct Check	33759-Scientific misconduct check.pdf
Scientific Editor Work List	33759-Scientific editor work list.pdf