Publication Name	World Journal of Gastroenterology
Manuscript ID	33776
Country	Canada

Received	2017-03-02 11:25
Peer-Review Started	2017-03-02 12:30
To Make the First Decision	2017-04-21 10:03
Return for Revision	2017-04-27 20:20
Revised	2017-05-07 20:12
Second Decision	2017-06-27 06:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-04 05:55
Articles in Press	2017-07-04 05:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-09-14 11:17
Publish the Manuscript Online	2017-09-25 08:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Basic Study
Article Title	Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1
Manuscript Source	Invited Manuscript
All Author List	Yirui Gui, Md Gulam Moussawir Khan, Diwakar Bobbala, Claire Dubois, Sheela Ramanathan, Caroline Saucier and Subburaj Ilangumaran
Funding Agency and Grant Number	Funding Agency Grant Number Cancer Research Society, Montreal, Canada 16195
Corresponding Author	Subburaj Ilangumaran, PhD, Department of Pediatrics, Immunology Division, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001 North 12th avenue, Sherbrooke J1H 5N4, Québec, Canada. subburaj.ilangumaran@usherbrooke.ca
Key Words	Migration; Invasion; MET; Hepatocellular carcinoma; Suppressor of cytokine signaling 1
Core Tip	The suppressor of cytokine signaling 1 (SOCS1) gene is frequently repressed in primary hepatocellular carcinoma (HCC) specimens, and mice lacking SOCS1 are highly susceptible to experimental HCC. The tumor suppressor functions of SOCS1 in HCC are not yet fully understood. We have shown that SOCS1 regulates hepatocyte growth factor signaling via the MET receptor in HCC cells and inhibits their growth. In this study, we characterize SOCS1 as a regulator of MET-mediated migration and invasion of HCC cells. We propose that SOCS1 gene expression status could be exploited as a selection marker for precision therapies targeting MET in HCC.
Publish Date	2017-09-25 08:56
Citation	Gui Y, Khan MGM, Bobbala D, Dubois C, Ramanathan S, Saucier C, Ilangumaran S. Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1. World J Gastroenterol 2017; 23(36): 6639-6649
URL	http://www.wjgnet.com/1007-9327/full/v23/i36/6639.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i36.6639

Full Article (PDF)	WJG-23-6639.pdf
Full Article (Word)	WJG-23-6639.doc
Manuscript File	33776-Review.docx
Answering Reviewers	33776-Answering reviewers.pdf
Audio Core Tip	33776-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33776-Conflict-of-interest statement.pdf
Copyright License Agreement	33776-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	33776-Institutional animal care and use committee statement.pdf
Peer-review Report	33776-Peer-review(s).pdf
Scientific Misconduct Check	33776-Scientific misconduct check.pdf
Scientific Editor Work List	33776-Scientific editor work list.pdf