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9/25/2017 8:56:57 AM | Browse: 942 | Download: 1347
Publication Name World Journal of Gastroenterology
Manuscript ID 33776
Country/Territory Canada
Received
2017-03-02 11:25
Peer-Review Started
2017-03-02 12:30
To Make the First Decision
2017-04-21 10:03
Return for Revision
2017-04-27 20:20
Revised
2017-05-07 20:12
Second Decision
2017-06-27 06:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-07-04 05:55
Articles in Press
2017-07-04 05:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-14 11:17
Publish the Manuscript Online
2017-09-25 08:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1
Manuscript Source Invited Manuscript
All Author List Yirui Gui, Md Gulam Moussawir Khan, Diwakar Bobbala, Claire Dubois, Sheela Ramanathan, Caroline Saucier and Subburaj Ilangumaran
Funding Agency and Grant Number
Funding Agency Grant Number
Cancer Research Society, Montreal, Canada 16195
Corresponding Author Subburaj Ilangumaran, PhD, Department of Pediatrics, Immunology Division, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001 North 12th avenue, Sherbrooke J1H 5N4, Québec, Canada. subburaj.ilangumaran@usherbrooke.ca
Key Words Migration; Invasion; MET; Hepatocellular carcinoma; Suppressor of cytokine signaling 1
Core Tip The suppressor of cytokine signaling 1 (SOCS1) gene is frequently repressed in primary hepatocellular carcinoma (HCC) specimens, and mice lacking SOCS1 are highly susceptible to experimental HCC. The tumor suppressor functions of SOCS1 in HCC are not yet fully understood. We have shown that SOCS1 regulates hepatocyte growth factor signaling via the MET receptor in HCC cells and inhibits their growth. In this study, we characterize SOCS1 as a regulator of MET-mediated migration and invasion of HCC cells. We propose that SOCS1 gene expression status could be exploited as a selection marker for precision therapies targeting MET in HCC.
Publish Date 2017-09-25 08:56
Citation Gui Y, Khan MGM, Bobbala D, Dubois C, Ramanathan S, Saucier C, Ilangumaran S. Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1. World J Gastroenterol 2017; 23(36): 6639-6649
URL http://www.wjgnet.com/1007-9327/full/v23/i36/6639.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i36.6639
Full Article (PDF) WJG-23-6639.pdf
Full Article (Word) WJG-23-6639.doc
Manuscript File 33776-Review.docx
Answering Reviewers 33776-Answering reviewers.pdf
Audio Core Tip 33776-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 33776-Conflict-of-interest statement.pdf
Copyright License Agreement 33776-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 33776-Institutional animal care and use committee statement.pdf
Peer-review Report 33776-Peer-review(s).pdf
Scientific Misconduct Check 33776-Scientific misconduct check.pdf
Scientific Editor Work List 33776-Scientific editor work list.pdf