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Articles Published Processes
8/19/2017 11:33:54 AM | Browse: 1213 | Download: 1317
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Received |
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2017-03-07 10:20 |
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Peer-Review Started |
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2017-03-07 17:34 |
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To Make the First Decision |
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2017-04-21 09:35 |
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Return for Revision |
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2017-04-24 16:20 |
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Revised |
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2017-06-11 15:19 |
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Second Decision |
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2017-06-16 12:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-06-19 09:14 |
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Articles in Press |
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2017-06-19 09:14 |
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Publication Fee Transferred |
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2017-06-22 07:25 |
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Edit the Manuscript by Language Editor |
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2017-07-03 05:28 |
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Typeset the Manuscript |
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2017-08-11 02:47 |
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Publish the Manuscript Online |
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2017-08-19 11:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Metabolomic profiling for identification of metabolites and relevant pathways for taurine in hepatic stellate cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin Deng, Xing-Qiu Liang, Fei-Guo Lu, Xiao-Fang Zhao, Lei Fu and Jian Liang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81360595 |
| National Natural Science Foundation of China |
81360532 |
| Guangxi Natural Science Foundation Program |
2014GXNSFDA118027 |
| Bagui Scholars Foundation Program of Guangxi |
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| Special-term Experts Foundation Program of Guangxi |
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| Corresponding Author |
Jian Liang, MD, Professor, Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Nanning 541100, Guangxi Zhuang Autonomous Region, China. dr_jianliang@163.com |
| Key Words |
Natural taurine; Hepatic stellate cells; Pathway; high performance liquid chromatography-time electrospray ionization/quadrupole-time of flight mass spectrometry; Metabolomics |
| Core Tip |
At the cellular level, it is reported that the activation of hepatic stellate cells (HSCs) in the subendothelial space may result in hepatic fibrosis. Although taurine was found to increase HSC apoptosis significantly, its molecular mechanisms are still unknown. This study developed a reliable and simple method to identify important biological metabolites and relevant pathways for taurine in HSCs, in order to provide more data for taurine therapy. We found that there were distinct changes in the biological metabolites of taurine in HSCs, and identified three differential metabolic pathways that might be of key importance in mediating the mechanism of action of taurine in HSCs. |
| Publish Date |
2017-08-19 11:33 |
| Citation |
Deng X, Liang XQ, Lu FG, Zhao XF, Fu L, Liang J. Metabolomic profiling for identification of metabolites and relevant pathways for taurine in hepatic stellate cells. World J Gastroenterol 2017; 23(31): 5713-5721 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i31/5713.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i31.5713 |
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