Publication Name	World Journal of Gastroenterology
Manuscript ID	3385
Country	Japan

Received	2013-04-26 08:55
Peer-Review Started	2013-04-26 20:19
First Decision by Editorial Office Director
Return for Revision	2013-06-20 19:08
Revised	2013-07-07 10:29
Publication Fee Transferred
Second Decision by Editor	2013-07-24 16:13
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-07-25 04:12
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-22 11:49
Publish the Manuscript Online	2013-09-09 09:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1
Manuscript Source	Invited Manuscript
All Author List	Atsushi Iraha, Hiroshi Chinen, Akira Hokama, Takumi Yonashiro, Tetsu Kinjo, Kazuto Kishimoto, Manabu Nakamoto, Tetsuo Hirata, Nagisa Kinjo, Futoshi Higa, Masao Tateyama, Fukunori Kinjo and Jiro Fujita
Funding Agency and Grant Number
Corresponding Author	Akira Hokama, MD, PhD, Assistant Professor, Department of Infectious, Respiratory, and Digestive Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan. hokama-a@med.u-ryukyu.ac.jp
Key Words	Fucoidan; Tight junction; Intestinal epithelial cells; Oxidative stress; Inflammatory bowel diseases
Core Tip	The oxidative stress-induced disruption of the intestinal epithelial cells and subsequent increased paracellular permeability are critically important in the pathogenesis of inflammatory bowel diseases (IBD). A growing body of experimental evidence indicates that fucoidan, a dietary substance of fucose-enriched sulfated polysaccharides, display a wide variety of pharmacological anti-inflammatory activities. This study demonstrates that fucoidan protected the epithelial barrier function from oxidative injury of the tight junction as well as barrier disruption by upregulating the expression of claudin-1. Thus, fucoidan may be an appropriate therapy for the treatment of IBD.
Publish Date	2013-09-09 09:30
Citation	Iraha A, Chinen H, Hokama A, Yonashiro T, Kinjo T, Kishimoto K, Nakamoto M, Hirata T, Kinjo N, Higa F, Tateyama M, Kinjo F, Fujita J. Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1. World J Gastroenterol 2013; 19(33): 5500-5507
URL	http://www.wjgnet.com/1007-9327/full/v19/i33/5500.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i33.5500

Full Article (PDF)	WJG-19-5500.pdf
Manuscript File	3385-Review.doc
Answering Reviewers	3385-Answering reviewers.pdf
Copyright License Agreement	3385-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	DC2F-F427-72B4-DE3E-DF0F.pdf
Peer-review Report	3385-Peer review(s).pdf