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Publication Name World Journal of Gastroenterology
Manuscript ID 3385
Country/Territory Japan
2013-04-26 08:55
Peer-Review Started
2013-04-26 20:19
To Make the First Decision
2013-06-09 10:03
Return for Revision
2013-06-20 19:08
2013-07-07 10:29
Second Decision
2013-07-24 16:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-07-25 04:12
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-08-22 11:49
Publish the Manuscript Online
2013-09-09 09:30
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1
Manuscript Source Invited Manuscript
All Author List Atsushi Iraha, Hiroshi Chinen, Akira Hokama, Takumi Yonashiro, Tetsu Kinjo, Kazuto Kishimoto, Manabu Nakamoto, Tetsuo Hirata, Nagisa Kinjo, Futoshi Higa, Masao Tateyama, Fukunori Kinjo and Jiro Fujita
Funding Agency and Grant Number
Corresponding author Akira Hokama, MD, PhD, Assistant Professor, Department of Infectious, Respiratory, and Digestive Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan. hokama-a@med.u-ryukyu.ac.jp
Keywords Fucoidan; Tight junction; Intestinal epithelial cells; Oxidative stress; Inflammatory bowel diseases
Core Tip The oxidative stress-induced disruption of the intestinal epithelial cells and subsequent increased paracellular permeability are critically important in the pathogenesis of inflammatory bowel diseases (IBD). A growing body of experimental evidence indicates that fucoidan, a dietary substance of fucose-enriched sulfated polysaccharides, display a wide variety of pharmacological anti-inflammatory activities. This study demonstrates that fucoidan protected the epithelial barrier function from oxidative injury of the tight junction as well as barrier disruption by upregulating the expression of claudin-1. Thus, fucoidan may be an appropriate therapy for the treatment of IBD.
Publish Date 2013-09-09 09:30
Citation Iraha A, Chinen H, Hokama A, Yonashiro T, Kinjo T, Kishimoto K, Nakamoto M, Hirata T, Kinjo N, Higa F, Tateyama M, Kinjo F, Fujita J. Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1. World J Gastroenterol 2013; 19(33): 5500-5507
Url http://www.wjgnet.com/1007-9327/full/v19/i33/5500.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i33.5500
Full Article (PDF) WJG-19-5500.pdf
Manuscript File 3385-Review.doc
Answering Reviewers 3385-Answering reviewers.pdf
Copyright License Agreement 3385-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate DC2F-F427-72B4-DE3E-DF0F.pdf
Peer-review Report 3385-Peer review(s).pdf
Scientific Editor Work List 3385-Scientific editor work list.doc