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Articles Published Processes
9/14/2017 3:13:08 AM | Browse: 918 | Download: 1586
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Received |
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2017-03-08 10:09 |
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Peer-Review Started |
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2017-03-09 10:01 |
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To Make the First Decision |
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2017-04-21 09:35 |
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Return for Revision |
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2017-04-24 16:19 |
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Revised |
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2017-05-02 01:24 |
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Second Decision |
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2017-05-27 01:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-06-01 07:00 |
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Articles in Press |
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2017-06-01 07:00 |
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Publication Fee Transferred |
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2017-06-07 03:47 |
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Edit the Manuscript by Language Editor |
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2017-07-09 02:52 |
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Typeset the Manuscript |
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2017-08-29 08:24 |
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Publish the Manuscript Online |
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2017-09-14 03:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non- commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Changes of Ghrelin/GOAT axis and mTOR pathway in the hypothalamus after sleeve gastrectomy in obese type-2 diabetes rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qiang Wang, Wei Tang, Wen-Sheng Rao, Xin Song, Cheng-Xiang Shan and Wei Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81270969 (to Zhang Wei) |
| National Natural Science Foundation of China |
81300723 (to Shan Cheng-Xiang) |
| Shanghai Science and Technology Commission Foundation |
12ZR1439100 (to Zhang Wei) |
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| Corresponding Author |
Zhang Wei, Professor, Department of General Surgery, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai 200003, China. zhangwei412@aliyun.com |
| Key Words |
Ghrelin; Ghrelin O-acyltransferase; Type-2 Diabetes; Hypothalamus; Obesity; Sleeve gastrectomy; Mammalian target of rapamycin |
| Core Tip |
Recent studies have demonstrated a complex relationship between ghrelin, ghrelin O-acyltransferase (GOAT) and the mammalian target of rapamycin (mTOR) pathway. In our study, we examined the changes of the ghrelin/GOAT axis and the mTOR pathway in the hypothalamus after sleeve gastrectomy (SG). The mRNA and protein levels of ghrelin and GOAT decreased after SG, while NPY mRNA expression did not change. We also found that SG increased the protein levels of p-Akt, p-mTOR and p-S6. The reduction of ghrelin expression and activation of the mTOR pathway might have opposite effects on food intake. These findings might explain the weight, glucose and food intake regain after SG. |
| Publish Date |
2017-09-14 03:13 |
| Citation |
Wang Q, Tang W, Rao WS, Song X, Shan CX, Zhang W. Changes of Ghrelin/GOAT axis and mTOR pathway in the hypothalamus after sleeve gastrectomy in obese type-2 diabetes rats. World J Gastroenterol 2017; 23(34): 6231-6241 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i34/6231.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i34.6231 |
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