Publication Name	World Journal of Orthopedics
Manuscript ID	33884
Country	Finland

Received	2017-03-15 10:38
Peer-Review Started	2017-03-17 09:36
To Make the First Decision	2017-07-10 00:34
Return for Revision	2017-07-11 02:17
Revised	2017-07-22 21:11
Second Decision	2017-08-10 03:39
Accepted by Journal Editor-in-Chief	2017-08-10 21:12
Accepted by Executive Editor-in-Chief	2017-08-16 02:36
Articles in Press	2017-08-16 02:36
Publication Fee Transferred	2017-09-01 08:57
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-09-21 03:00
Publish the Manuscript Online	2017-10-18 02:31

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Retrospective Study
Article Title	Total joint replacement in inhibitor-positive haemophilia: Long-term outcome analysis in fifteen patients
Manuscript Source	Unsolicited Manuscript
All Author List	Heidi Danielson, Riitta Lassila, Pekka Ylinen and Timo Yrjönen
Funding Agency and Grant Number
Corresponding Author	Timo Yrjönen, MD, PhD, Orton Orthopaedic Hospital, Invalid Foundation, Tenholantie 10, Helsinki 00280, Finland. timo.yrjonen@orton.fi
Key Words	Haemophilia; Joint replacement; Inhibitor; Cost analysis; Arthroplasty
Core Tip	There are only few reports including joint arthroplasties on inhibitor-positive haemophilia patients. Generally the focus is mainly on immediate haemostatic outcome leaving the long-term orthopaedic results unreported. Our study brings out the importance of long-term and overall outcome when performing elective life-quality surgery. Management of inhibitor patients is especially challenging regarding not only the operative treatment but also the costs. As the health economic analysis of the topic is lacking, we provide new data. According to our cost analysis, preoperative immune-tolerance induction for high responder patients will bring cost- and outcome benefit both in surgery and preventing postoperative bleeds.
Publish Date	2017-10-18 02:31
Citation	Danielson H, Lassila R, Ylinen P, Yrjönen T. Total joint replacement in inhibitor-positive haemophilia: Long-term outcome analysis in fifteen patients. World J Orthop 2017; 8(10): 777-784
URL	http://www.wjgnet.com/2218-5836/full/v8/i10/777.htm
DOI	http://dx.doi.org/10.5312/wjo.v8.i10.777

Full Article (PDF)	WJO-8-777.pdf
Full Article (Word)	WJO-8-777.doc
Manuscript File	33884-Review.doc
Answering Reviewers	33884-Answering reviewers.pdf
Audio Core Tip	33884-Audio core tip.wav
Biostatistics Review Certificate	33884-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	33884-Conflict-of-interest statement.pdf
Copyright License Agreement	33884-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	33884-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	33884-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	33884-Language certificate.pdf
Peer-review Report	33884-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33884-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	33884-Scientific misconduct check.pdf
Scientific Editor Work List	33884-Scientific editor work list.pdf