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Articles Published Processes
7/7/2017 11:41:16 AM | Browse: 1196 | Download: 2214
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Received |
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2017-03-14 10:32 |
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Peer-Review Started |
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2017-03-15 16:36 |
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To Make the First Decision |
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2017-03-30 13:24 |
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Return for Revision |
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2017-03-31 16:17 |
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Revised |
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2017-04-04 20:26 |
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Second Decision |
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2017-04-27 18:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-05-04 18:37 |
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Articles in Press |
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2017-05-04 18:37 |
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Publication Fee Transferred |
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2017-05-18 04:27 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-06-24 15:02 |
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Publish the Manuscript Online |
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2017-07-07 11:41 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Seung Kak Shin, Jae Hee Cho, Eui Joo Kim, Eun-Kyung Kim, Dong Kyun Park, Kwang An Kwon, Jun-Won Chung, Kyoung Oh Kim and Yoon Jae Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning |
2014R1A1A1A05008202 |
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| Corresponding Author |
Yoon Jae Kim, MD, PhD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Gachon University Gil Medical Center, 21, Namdong-daero 774 beon-gil, Namdong-gu, Incheon 21565, South Korea. yoonmed@gachon.ac.kr |
| Key Words |
Oxidative stress; Inflammatory bowel disease; Rosuvastatin; Apoptosis |
| Core Tip |
Oxidative stress in the intestinal tract is considered a major factor that contributes to the pathogenesis and progression of inflammatory bowel disease (IBD). We report that rosuvastatin has the antioxidant, anti-inflammatory and anti-apoptotic effects in dextran sulfate sodium (DSS)-induced colitis mice. We assume the possibility of anti-inflammatory effects of rosuvastatin through the regulation of oxidative stress, and first describe the anti-apoptotic effects of rosuvastatin in a DSS-induced colitis model. Therefore, rosuvastatin might be a candidate anti-inflammatory drug in patients with IBD. |
| Publish Date |
2017-07-07 11:41 |
| Citation |
Shin SK, Cho JH, Kim EJ, Kim EK, Park DK, Kwon KA, Chung JW, Kim KO, Kim YJ. Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model. World J Gastroenterol 2017; 23(25): 4559-4568 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i25/4559.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i25.4559 |
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