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Articles Published Processes
8/14/2017 4:00:08 AM | Browse: 975 | Download: 1807
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Received |
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2017-03-14 09:10 |
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Peer-Review Started |
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2017-03-14 19:48 |
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To Make the First Decision |
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2017-04-20 13:52 |
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Return for Revision |
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2017-04-20 16:19 |
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Revised |
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2017-05-10 00:13 |
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Second Decision |
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2017-06-27 00:39 |
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Accepted by Journal Editor-in-Chief |
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2017-06-28 08:37 |
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Accepted by Executive Editor-in-Chief |
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2017-07-04 06:12 |
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Articles in Press |
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2017-07-04 06:12 |
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Publication Fee Transferred |
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2017-07-14 09:54 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-08-02 12:46 |
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Publish the Manuscript Online |
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2017-08-14 04:00 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Crohn’s disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Valéria Cristina Loureiro Salgado, Ronir Raggio Luiz, Neio Boechat, Bianca C Schorr, Isabella S Leão, Tiago Nunes and Cyrla Zaltman |
| Funding Agency and Grant Number |
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| Corresponding Author |
Cyrla Zaltman, Division of Gastro¬enterology, Department of Internal Medicine, Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, Ilha do Fundão, Rio de Janeiro 21941-913, Brazil. c.zaltman@gmail.com |
| Key Words |
Crohn’s disease; Environment; Hygiene hypothesis; Risk factors |
| Core Tip |
This case-control study aimed to revisit the hygiene hypothesis in inflammatory bowel disease with the inclusion of Crohn’s disease (CD) patients and healthy controls representing a socioeconomically diverse statewide catchment area in Brazil. Subjects completed an extensive 94-item survey regarding perinatal and childhood circumstances, living conditions, smoking and familial socioeconomic status. Most variables supporting the hygiene hypothesis were associated with CD but were not independent predictors of the diagnosis. These findings suggest that, albeit there is an association, the influence that these variables might have on disease development is not as strong as other classic environmental factors (smoking) found to be closely related to disease onset and progression. |
| Publish Date |
2017-08-14 04:00 |
| Citation |
Salgado VCL, Luiz RR, Boechat N, Schorr BC, Leão IS, Nunes T, Zaltman C. Crohn’s disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil. World J Gastroenterol 2017; 23(30): 5549-5556 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i30/5549.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i30.5549 |
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