Publication Name	World Journal of Gastroenterology
Manuscript ID	33973
Country	Italy

Received	2017-03-18 16:10
Peer-Review Started	2017-03-21 19:45
To Make the First Decision	2017-04-26 08:48
Return for Revision	2017-04-27 20:32
Revised	2017-05-01 16:23
Second Decision	2017-06-27 06:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-04 05:56
Articles in Press	2017-07-04 05:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-31 11:29
Publish the Manuscript Online	2017-08-07 09:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Liver and the defects of cholesterol and bile acids biosynthesis: Rare disorders many diagnostic pitfalls
Manuscript Source	Invited Manuscript
All Author List	Gaetano Corso, Antonio Dello Russo and Monica Gelzo
Funding Agency and Grant Number
Corresponding Author	Monica Gelzo, PhD, Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via Pansini 5, Naples 80131, Italy. monicagelzo@gmail.com
Key Words	Cholesterol; Bile acids; Liver metabolism; Gas chromatography coupled to mass spectrometry; Liquid chromatography coupled to tandem mass spectrometry
Core Tip	The genetic defects of cholesterol and bile acid biosynthesis are characterized by a diversity of clinical findings affecting the liver, the intestine, and the nervous system. Many of these defects are efficaciously treatable but owing to mild phenotypes many cases can escape to an earlier diagnosis and are identified after few years or adulthood with irreversible injuries or more difficult to treat. Here, we highlighted simple clinical and laboratory descriptions that can potentially make you to suspect a defect in cholesterol biosynthesis and/or bile acids, in order to reduce the diagnostic delay and to improve the prognosis of these defects.
Publish Date	2017-08-07 09:17
Citation	Corso G, Dello Russo A, Gelzo M. liver and the defects of cholesterol and bile acids biosynthesis: Rare disorders many diagnostic pitfalls. World J Gastroenterol 2017; 23(29): 5257-5265
URL	http://www.wjgnet.com/1007-9327/full/v23/i29/5257.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i29.5257

Full Article (PDF)	WJG-23-5257.pdf
Full Article (Word)	WJG-23-5257.doc
Manuscript File	33973-Review.docx
Answering Reviewers	33973_33973-answewring reviewers .doc
Audio Core Tip	33973-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33973-Conflict-of-interest statement.pdf
Copyright License Agreement	33973-Copyright assignment.pdf
Peer-review Report	33973-Peer-review(s).pdf
Scientific Misconduct Check	33973-Scientific misconduct check.pdf
Scientific Editor Work List	33973-Scientific editor work list.pdf