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Articles Published Processes
9/28/2017 10:01:54 AM | Browse: 875 | Download: 1449
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Received |
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2017-03-21 10:26 |
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Peer-Review Started |
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2017-03-22 17:30 |
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To Make the First Decision |
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2017-04-21 10:02 |
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Return for Revision |
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2017-04-27 20:49 |
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Revised |
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2017-05-12 02:59 |
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Second Decision |
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2017-07-12 09:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-07-24 08:01 |
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Articles in Press |
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2017-07-24 08:01 |
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Publication Fee Transferred |
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2017-09-07 02:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-09-23 07:39 |
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Publish the Manuscript Online |
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2017-09-28 10:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Janaki K Iyer, Mamta Kalra, Anil Kaul, Mark E Payton and Rashmi Kaul |
| Funding Agency and Grant Number |
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| Corresponding Author |
Rashmi Kaul, PhD, Associate Professor, Department of Biochemistry and Microbiology, Oklahoma State University - Center for Health Sciences, Tulsa, OK 74012, United States. rashmi.kaul10@okstate.edu |
| Key Words |
Estrogen receptor α; Estrogen receptor β; Hepatitis C virus-related cirrhosis; Hepatitis C virus-related hepatocellular carcinoma; Sex and gender; Normal liver |
| Core Tip |
Our study, for the first time, demonstrates gender-based differences in basal expression of estrogen receptor α (ERα) in the liver of normal males and females. Altered nuclear and cytoplasm liver ER subtype protein expression was also observed in hepatitis C virus (HCV)-cirrhosis and HCV-related hepatocellular carcinoma (HCC) that correlate with the inflammatory and oncogenic markers activated NF-κB and cyclin D1 implicating their role in chronic cirrhosis and malignant transformation. These findings may have an impact on future planning strategies for the development of novel treatments or prognostic markers by targeting ERs or their signaling pathways during chronic HCV-related cirrhosis and HCC development. |
| Publish Date |
2017-09-28 10:01 |
| Citation |
Iyer JK, Kalra M, Kaul A, Payton ME, Kaul R. Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis. World J Gastroenterol 2017; 23(37): 6802-6816 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i37/6802.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i37.6802 |
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