Publication Name	World Journal of Hematology
Manuscript ID	34006
Country	Netherlands

Received	2017-03-20 13:03
Peer-Review Started	2017-03-24 08:27
To Make the First Decision	2017-04-14 08:13
Return for Revision	2017-04-18 13:58
Revised	2017-04-27 08:45
Second Decision	2017-07-06 09:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-17 06:13
Articles in Press	2017-07-17 06:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-04 03:02
Publish the Manuscript Online	2017-08-07 04:59

ISSN	2218-6204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Hematology
Manuscript Type	Review
Article Title	Aspirin cures erythromelalgia and cerebrovascular disturbances in JAK2-thrombocythemia through platelet-cycloxygenase inhibition
Manuscript Source	Invited Manuscript
All Author List	Jan Jacques Michiels
Funding Agency and Grant Number
Corresponding Author	Jan Jacques Michiels, MD, PhD, Doctor, Doctor, Professor, Goodheart Insitute Freedom of Science and Education in Nature Medicine and Health, Erasmus Tower, Veenmos 13, Rotterdam 3969 AT, Netherlands. goodheartcenter@upcmail.nl
Key Words	Aspirin; Wonder drug; Erythromelalgia; Cerebral vascular disturbances; Platelet cyclooxygenase; Migraine
Core Tip	About seventy years after the synthesis by Hoffmann, acetyl salicylic acid (aspirin) has been discovered in the late 1970s as a wunder drug that cures erythromelalgia and migraine-like cerebral microvascular disturbances by irreversible blockage of platelet cyclo-oxygenase mediated arteriolar inflammation and thrombosis in JAK2-mutated thrombocythemia of patients with essential thrombocythemia (ET) and polycythemia vera (PV). The ADP (P2Y12) receptor inhibtors ticlopedin and clopidogrel, other platelet inhibitors that do not affect platelet cycooxygenase, and coumarin are ineffective in the treatment of erythromelalgia and cerebral vascular thrombotic complications in ET and PV.
Publish Date	2017-08-07 04:59
Citation	Michiels JJ. Aspirin cures erythromelalgia and cerebrovascular disturbances in JAK2-thrombocythemia through platelet-cycloxygenase inhibition. World J Hematol 2017; 6(3): 32-54
URL	http://www.wjgnet.com/2218-6204/full/v6/i3/32.htm
DOI	http://dx.doi.org/10.5315/wjh.v6.i3.32

Full Article (PDF)	WJH-6-32.pdf
Full Article (Word)	WJH-6-32.doc
Manuscript File	34006-Review.docx
Answering Reviewers	34006-Answering reviewers.pdf
Audio Core Tip	34006-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	34006-Conflict-of-interest statement.pdf
Copyright License Agreement	34006-Copyright assignment.pdf
Peer-review Report	34006-Peer-review(s).pdf
Scientific Misconduct Check	34006-Scientific misconduct check.pdf
Scientific Editor Work List	34006-Scientific editor work list.pdf