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Articles Published Processes
9/25/2017 8:56:57 AM | Browse: 1137 | Download: 2476
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Received |
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2017-03-23 17:20 |
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Peer-Review Started |
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2017-03-23 19:01 |
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To Make the First Decision |
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2017-04-26 08:46 |
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Return for Revision |
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2017-04-28 10:45 |
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Revised |
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2017-07-14 03:11 |
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Second Decision |
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2017-07-21 07:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-07-24 08:02 |
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Articles in Press |
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2017-07-24 08:02 |
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Publication Fee Transferred |
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2017-08-24 08:21 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-09-16 12:49 |
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Publish the Manuscript Online |
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2017-09-25 08:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Protective effects of oral glutathione on fasting-induced intestinal atrophy through oxidative stress
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hiroyuki Uchida, Yukari Nakajima, Kazuo Ohtake, Junta Ito, Masahiko Morita, Ayako Kamimura and Jun Kobayashi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Kyowa Hakko Bio Co., Ltd. |
to Uchida H |
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| Corresponding Author |
Hiroyuki Uchida, Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. mrhiro@josai.ac.jp |
| Key Words |
Intestinal atrophy; Glutathione; Apoptosis; Cell proliferation; Inducible nitric oxide synthase |
| Core Tip |
We have previously demonstrated that the intestinal mucosal atrophy consequent to fasting is due in large part to increased apoptosis in jejunal villi and decreased cell proliferation in jejunal crypts, with concomitant increased reactive oxygen species (ROS) and NO production and decreased glutathione (GSH). Here we demonstrate protection against fasting-induced intestinal mucosal atrophy by minimizing ROS induction in the intestinal mucosa through supplemental oral administration of an antioxidant such as GSH during fasting in rats. In particular, oral GSH administration during fasting enhances jejunal regenerative potential by diminishing enterocyte apoptosis and enhancing cell proliferation. |
| Publish Date |
2017-09-25 08:56 |
| Citation |
Uchida H, Nakajima Y, Ohtake K, Ito J, Morita M, Kamimura A, Kobayashi J. Protective effects of oral glutathione on fasting-induced intestinal atrophy through oxidative stress. World J Gastroenterol 2017; 23(36): 6650-6664 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i36/6650.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i36.6650 |
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