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Articles Published Processes
7/20/2017 10:12:50 AM | Browse: 940 | Download: 1739
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Received |
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2017-04-05 11:30 |
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Peer-Review Started |
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2017-04-10 08:24 |
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To Make the First Decision |
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2017-04-26 08:54 |
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Return for Revision |
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2017-04-28 17:22 |
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Revised |
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2017-05-10 18:19 |
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Second Decision |
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2017-06-16 13:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-06-19 09:45 |
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Articles in Press |
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2017-06-19 09:45 |
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Publication Fee Transferred |
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2017-06-22 09:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-07-14 02:22 |
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Publish the Manuscript Online |
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2017-07-20 10:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Takanobu Takata, Tadashi Ueda, Akiko Sakasai-Sakai and Masayoshi Takeuchi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grants from Japan Society for the Promotion of Science (JSPS) KAKENHI Grant |
25282029 |
| Grants from Japan Society for the Promotion of Science (JSPS) KAKENHI Grant |
26750056 |
| Grants from Japan Society for the Promotion of Science (JSPS) KAKENHI Grant |
16H01811 |
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| Corresponding Author |
Takanobu Takata, PhD, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan. takajjjj@kanazawa-med.ac.jp |
| Key Words |
Tumor promotion; Glyceraldehyde-derived advanced glycation-end products; Pancreatic ductal adenocarcinoma |
| Core Tip |
The mechanisms promoting pancreatic ductal adenocarcinoma (PDAC) in the pancreas of Type 2 diabetes mellitus patients have not yet been elucidated. We hypothesized that glyceraldehyde (GA)-derived advanced glycation-end products (GA-AGEs) promote PDAC. PANC-1 cells were treated with GA, which induced the production of intracellular GA-AGEs and cell death. The high-molecular-weight complexes of heat shock proteins were produced after GA treatment in a dose-dependent manner. GA-AGEs-bovine serum albumin promoted the proliferation of PANC-1 cells. Although intracellular GA-AGEs induce pancreatic cancer cell death, their secretion and release may promote the proliferation of other pancreatic cancer cells. |
| Publish Date |
2017-07-20 10:12 |
| Citation |
Takata T, Ueda T, Sakasai-Sakai A, Takeuchi M. Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion. World J Gastroenterol 2017; 23(27): 4910-4919 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i27/4910.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i27.4910 |
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