Publication Name	World Journal of Hepatology
Manuscript ID	34072
Country	Serbia

Received	2017-03-25 13:34
Peer-Review Started	2017-03-28 18:27
To Make the First Decision	2017-06-14 01:07
Return for Revision	2017-06-30 12:58
Revised	2017-08-16 12:26
Second Decision	2017-09-08 01:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-09-18 02:03
Articles in Press	2017-09-18 02:03
Publication Fee Transferred	2017-10-02 17:59
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-10-25 01:50
Publish the Manuscript Online	2017-10-27 00:23

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review
Manuscript Source	Unsolicited Manuscript
All Author List	Nikica M Grubor, Katica D Jovanova-Nesic and Yehuda Shoenfeld
Funding Agency and Grant Number
Corresponding Author	Katica D Jovanova-Nesic, PhD, Immunology Research Center, Institute of Virology, Vaccine and Sera-Torlak, Vojvode Stepe 458, Belgrade 11221, Serbia. jovanok@afrodita.rcub.bg.ac.rs
Key Words	Lymphocytes; Dendritic cells; Immunity; Autoimmunity; Cytokines; Echinococcus granulosus
Core Tip	The most common location of a hydatid echinococcal cyst is in the liver. The survival of Echinococcus within host tissues, despite the development of specific antibodies, is possible due to specific immunomodulation induced by parasites. Perpetual survival of parasites indicating multi-level systematic evasion against host protective reaction to persist their growth and spreading. Complement modulation, a metabolic adaptation to the host microenvironment, plentiful thermostable immunogenic antigen B in the cystic fluid, and induction of CD4+CD8+FOXP3+ T cells allows the persistence of the parasites. Parasites influence dendritic cell (DC) maturation and impair activation by toll-like receptor. It seems that DC-parasite interaction is pivotal in triggering and regulating parasite induced immunity.
Publish Date	2017-10-27 00:23
Citation	Grubor NM, Jovanova-Nesic KD, Shoenfeld Y. Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review. World J Hepatol 2017; 9(30): 1176-1189
URL	http://www.wjgnet.com/1948-5182/full/v9/i30/1176.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i30.1176

Full Article (PDF)	WJH-9-1176.pdf
Full Article (Word)	WJH-9-1176.doc
Manuscript File	34072-Review.docx
Answering Reviewers	34072-Answering-Reviewers-revision_1751.docx
Audio Core Tip	34072-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	34072-Conflict-of-Interest-Statement-revision_2228.pdf
Copyright License Agreement	34072-Copyright-Assignment-revision_1955.pdf
Non-Native Speakers of English Editing Certificate	34072-Non-Native-Speakers-of-English-revision_2535.pdf
Supplementary Material	34072-Supplementary-Material-revision.pptx
Peer-review Report	34072-Peer-review(s).pdf
Scientific Misconduct Check	34072-Scientific misconduct check.pdf
Scientific Editor Work List	34072-Scientific editor work list.pdf