Publication Name	World Journal of Experimental Medicine
Manuscript ID	34092
Country	Brazil

Received	2017-03-27 08:31
Peer-Review Started	2017-03-28 18:27
To Make the First Decision	2017-05-08 15:30
Return for Revision	2017-05-09 17:42
Revised	2017-06-11 11:21
Second Decision	2017-06-22 02:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-03 02:36
Articles in Press	2017-07-03 02:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-15 09:28
Publish the Manuscript Online	2017-08-18 02:46

ISSN	2220-315x (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Surgical and immune reconstitution murine models in bone marrow research: Potential for exploring mechanisms in sepsis, trauma and allergy
Manuscript Source	Invited Manuscript
All Author List	Pedro Xavier-Elsas, Renato Nunes Ferreira and Maria Ignez C Gaspar-Elsas
Funding Agency and Grant Number
Corresponding Author	Pedro Xavier-Elsas, MD, PhD, Associate Professor, Department of Immunology, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Bloco I, Room I-2-066, Rio de Janeiro 21941-590, Brazil. pxelsas@micro.ufrj.br
Key Words	Bone-marrow; Trauma; Repair; Transplantation; Surgery
Core Tip	Bone-marrow generates multiple cell types which may play important roles in repair at distant sites. The use of surgical models in the characterization of this emerging function has hitherto been limited. Surgical strategies allow nevertheless the experimenter to predetermine the site, timing, severity and invasiveness of injury; to add or remove aggravating factors (such as infection and defects in immunity) in controlled ways; and to manipulate the context of repair, including reconstitution with selected immune cell subpopulations. Here we review surgical models with great potential for exploring bone-marrow responses to injury, inflammation and infection.
Publish Date	2017-08-18 02:46
Citation	Xavier-Elsas P, Ferreira RN, Gaspar-Elsas MIC. Surgical and immune reconstitution murine models in bone marrow research: Potential for exploring mechanisms in sepsis, trauma and allergy. World J Exp Med 2017; 7(3): 58-77
URL	http://www.wjgnet.com/2220-315X/full/v7/i3/58.htm
DOI	http://dx.doi.org/10.5493/wjem.v7.i3.58

Full Article (PDF)	WJEM-7-58.pdf
Full Article (Word)	WJEM-7-58.doc
Manuscript File	34092-Review.docx
Answering Reviewers	34092-Answering reviewers.pdf
Audio Core Tip	34092-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	34092-Conflict-of-interest statement.pdf
Copyright License Agreement	34092-Copyright assignment.pdf
Peer-review Report	34092-Peer-review(s).pdf
Scientific Misconduct Check	34092-Scientific misconduct check.pdf
Scientific Editor Work List	34092-Scientific editor work list.pdf