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Articles Published Processes
9/14/2017 3:13:08 AM | Browse: 1006 | Download: 2200
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Received |
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2017-03-28 17:41 |
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Peer-Review Started |
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2017-04-01 12:13 |
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To Make the First Decision |
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2017-04-26 08:48 |
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Return for Revision |
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2017-04-28 11:21 |
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Revised |
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2017-05-15 09:19 |
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Second Decision |
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2017-06-16 12:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-06-19 08:44 |
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Articles in Press |
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2017-06-19 08:44 |
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Publication Fee Transferred |
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2017-06-26 02:02 |
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Edit the Manuscript by Language Editor |
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2017-07-04 11:40 |
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Typeset the Manuscript |
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2017-09-06 12:59 |
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Publish the Manuscript Online |
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2017-09-14 03:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Wu, Yan Cheng, Rong Zhang, Dong Liu, Yu-Mei Luo, Kun-Lun Chen, Song Ren and Jun Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| MIMS (Shanghai) Ltd. of China |
IDF-2013-07 |
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| Corresponding Author |
Dr. Jun Zhang, The Second Affiliated Hospital of School of Medicine, Xi’an Jiaotong University, No. 157 Xi Wu Road, Xi’an 710004, Shaanxi Province, China. junzh3z@163.com |
| Key Words |
Irritable bowel syndrome; P2Y1 receptor; regulation; therapy; visceral hypersensitivity |
| Core Tip |
P2Y1R is believed to be part of a high-sensitivity response to mechanical stimulation but whether it is involved in visceral hypersensitivity of irritable bowel syndrome is discussing. We detected its expression in the colon of a rat model of irritable bowel syndrome, and explored its regulatory role in visceral hypersensitivity with a specific agonist and an antagonist. The abdominal withdrawal reflex and electromyography tests showed effective changes after intervention. It was interesting to note that in case of combined treatment of the two drugs, the antagonist showed higher effects, which indicated that other P2 receptors might be involved in the hypersensitivity of irritable bowel syndrome. |
| Publish Date |
2017-09-14 03:13 |
| Citation |
Wu J, Cheng Y, Zhang R, Liu D, Luo YM, Chen KL, Ren S, Zhang J. P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome. World J Gastroenterol 2017; 23(34): 6339-6349 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i34/6339.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i34.6339 |
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