Publication Name	World Journal of Stem Cells
Manuscript ID	34130
Country	Brazil

Received	2017-03-29 10:15
Peer-Review Started	2017-03-31 16:02
To Make the First Decision	2017-04-17 09:17
Return for Revision	2017-04-18 15:30
Revised	2017-06-28 14:31
Second Decision	2017-06-29 08:30
Accepted by Journal Editor-in-Chief	2017-06-30 04:40
Accepted by Executive Editor-in-Chief	2017-07-10 02:56
Articles in Press	2017-07-10 02:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-09-13 06:04
Publish the Manuscript Online	2017-09-20 01:02

ISSN	1948-0210 (online)
Open Access
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireview
Manuscript Source	Invited Manuscript
All Author List	Danilo Candido de Almeida, Laura Sibele Martins Evangelista and Niels Olsen Saraiva Câmara
Funding Agency and Grant Number	Funding Agency Grant Number São Paulo Research Public Foundation FAPESP and National Counsel of Technological and Scientific Development CNPq 07/07193-3 São Paulo Research Public Foundation FAPESP and National Counsel of Technological and Scientific Development CNPq 12/02270-2
Corresponding Author	Danilo Candido de Almeida, PhD, Department of Medicine, Nephrology Division, Federal University of São Paulo, Rua Pedro de Toledo, 669 - 10 Andar - Frente, Vila Clementino, SP 04039-003, São Paulo, Brazil. d.almeida@unifesp.br
Key Words	Mesenchymal stromal cells; Aryl-hydrocarbon receptor; Cell activation and immunosuppression
Core Tip	The aryl-hydrocarbon receptor (AhR) is an endo¬genous sensor expressed in mesenchymal stromal cells (MSCs), regulating their immunomodulatory function. Therefore, in this review, we summarize important reports that demonstrate that AhR activation can substantially modulate the function of MSCs by mechanisms associated with: (1) The induction of the death signal in pro-inflammatory cells; (2) the suppression of pro-inflammatory genes/cytokines; (3) the improvement of migration and regenerative potential in acute inflammatory models; (4) the inhibition of mesodermal differentiation; and (5) the up-regulation of global immunosuppression. Thus, the influence of AhR activation on MSC function can establish new perspectives on MSC-based therapies, especially for immune-associated diseases.
Publish Date	2017-09-20 01:02
Citation	de Almeida DC, Evangelista LSM, Câmara NOS. Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireview. World J Stem Cells 2017; 9(9): 152-158
URL	http://www.wjgnet.com/1948-0210/full/v9/i9/152.htm
DOI	http://dx.doi.org/10.4252/wjsc.v9.i9.152

Full Article (PDF)	WJSC-9-152.pdf
Full Article (Word)	WJSC-9-152.doc
Manuscript File	34130-Review.docx
Answering Reviewers	34130-Answering-Reviewers-revision.pdf
Audio Core Tip	34130-Audio-revision.mp3
Conflict-of-Interest Disclosure Form	34130-Conflict-of-Interest-Statement-revision.pdf
Copyright License Agreement	34130-Copyright-Assignment-revision.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34130-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s)-revision.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20170329021351.pdf
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20170329021155.pdf
Non-Native Speakers of English Editing Certificate	34130-Non-Native-Speakers-of-English-revision.pdf
Peer-review Report	34130-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	34130-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	34130-Scientific misconduct check.pdf
Scientific Editor Work List	34130-Scientific editor work list.pdf