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Articles Published Processes
9/7/2017 8:51:55 AM | Browse: 1049 | Download: 1800
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Received |
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2017-03-31 17:07 |
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Peer-Review Started |
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2017-04-08 16:12 |
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To Make the First Decision |
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2017-05-12 09:09 |
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Return for Revision |
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2017-05-16 09:34 |
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Revised |
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2017-06-14 07:51 |
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Second Decision |
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2017-07-28 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-08-02 07:10 |
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Articles in Press |
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2017-08-02 07:10 |
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Publication Fee Transferred |
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2017-08-09 01:50 |
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Edit the Manuscript by Language Editor |
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2017-08-12 08:56 |
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Typeset the Manuscript |
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2017-09-04 02:46 |
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Publish the Manuscript Online |
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2017-09-07 08:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Aberrant DNA-PKcs and ERGIC1 expression may be involved in initiation of gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fu-Rong Wang, Yu-Cai Wei, Zhi-Jian Han, Wen-Ting He, Xiao-Ying Guan, Hao Chen and Yu-Min Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31270532 |
| National Natural Science Foundation of China |
81670594 |
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| Corresponding Author |
Yu-Min Li, Professor, Department of General Surgery, Second Hospital of Lanzhou University, 82 Cuiyingmen, Lanzhou 730000, Gansu Province, China. liym@lzu.edu.cn |
| Key Words |
DNA-PKcs; ERGIC1; dysplasia; proteomics; gastric cancer |
| Core Tip |
Using label-free combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS), the expression of 365 proteins based on the tendency of fold change was revealed to be statistically different between the various stages of gastric cancer (GC) initiation. Furthermore, we observed that ERGIC1 expression decreased, while DNA-PKcs expression increased gradually along with different stages of GC initiation based on the tendency of fold change. The expression patterns of ERGIC1 and DNA-PKcs revealed by immunohistochemistry were consistent with the LC-MS/MS results. These data indicate that abnormal ERGIC1 and DNA-PKcs expression may play an important role in GC initiation. |
| Publish Date |
2017-09-07 08:51 |
| Citation |
Wang FR, Wei YC, Han ZJ, He WT, Guan XY, Chen H, Li YM. Aberrant DNA-PKcs and ERGIC1 expression may be involved in initiation of gastric cancer. World J Gastroenterol 2017; 23(33): 6119-6127 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i33/6119.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i33.6119 |
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