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8/19/2017 11:33:54 AM | Browse: 200 | Download: 250
Publication Name World Journal of Gastroenterology
Manuscript ID 34162
Country of Manuscript Source Japan
Received
2017-04-01 09:03
Peer-Review Started
2017-04-08 18:14
To Make the First Decision
2017-04-26 08:47
Return for Revision
2017-04-28 11:51
Revised
2017-05-11 19:44
Second Decision
2017-07-21 07:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-07-24 08:02
Articles in Press
2017-07-24 08:02
Publication Fee Transferred
2017-07-27 09:27
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-14 03:57
Publish the Manuscript Online
2017-08-19 11:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Retrospective Study
Article Title Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Kohei Nishio, Kenjiro Kimura, Ryosuke Amano, Bunzo Nakata, Sadaaki Yamazoe, Go Ohira, Kotaro Miura, Naoki Kametani, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa and Masaichi Ohira
Funding Agency and Grant Number
Correspondence To Kenjiro Kimura, MD, PhD, Senior Lecturer, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan. kenjiro@med.osaka-cu.ac.jp
Keywords doublecortin and CaM kinase-like-1; Pancreatic cancer; Epithelial mesenchymal transition; Cancer stem cell; Prognostic factor
Core Tip Doublecortin and CaM kinase-like-1 (DCLK1) is a microtubule - associated kinase and has recently attracted much attention as an important cancer stem cell marker. DCLK1 expression is correlated with aggressiveness in various cancers. However, there have been few investigations correlating DCLK1 expression with survival in pancreatic ductal adenocarcinoma (PDAC). PDAC patients with DCLK1-positive tumors had significantly shorter survival times than those with DCLK1-negative tumors. DCLK1 expression was an independent prognostic factor by multivariate survival analysis. Furthermore, DCLK1-positive expression was correlated to EpCAM expression and triple-positive expression of CD44/CD24/EpCAM. These findings suggest DCLK1 may have a crucial prognostic role in acquisition of stemness.
Publish Date 2017-08-19 11:33
Citation Nishio K, Kimura K, Amano R, Nakata B, Yamazoe S, Ohira G, Miura K, Kametani N, Tanaka H, Muguruma K, Hirakawa K, Ohira M. Doublecortin and CaM kinase-like-1 as an independent poor prognostic factor for resected pancreatic carcinoma. World J Gastroenterol 2017; 23(31): 5764-5772
Url http://www.wjgnet.com/1007-9327/full/v23/i31/5764.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i31.5764
Full Article (PDF) WJG-23-5764.pdf
Full Article (Word) WJG-23-5764.doc
Manuscript File 34162-Review.docx
Answering Reviewers 34162-Answering reviewers.pdf
Audio Core Tip 34162-Audio core tip.mp3
Biostatistics Review Certificate 34162-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 34162-Conflict-of-interest statement.pdf
Copyright License Agreement 34162-Copyright assignment.pdf
Data Sharing Statement 34162-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) 34162-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 34162-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 34162-Language certificate.pdf
Scientific Research Process 34162-Scientific research process.pdf
Peer-review Report 34162-Peer-review(s).pdf
Scientific Misconduct Check 34162-Scientific misconduct check.pdf
Scientific Editor Work List 34162-Scientific editor work list.pdf