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Articles Published Processes
8/19/2017 11:33:54 AM | Browse: 1224 | Download: 1991
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Received |
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2017-04-01 09:03 |
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Peer-Review Started |
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2017-04-08 18:14 |
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To Make the First Decision |
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2017-04-26 08:47 |
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Return for Revision |
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2017-04-28 11:51 |
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Revised |
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2017-05-11 19:44 |
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Second Decision |
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2017-07-21 07:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-07-24 08:02 |
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Articles in Press |
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2017-07-24 08:02 |
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Publication Fee Transferred |
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2017-07-27 09:27 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-08-14 03:57 |
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Publish the Manuscript Online |
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2017-08-19 11:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kohei Nishio, Kenjiro Kimura, Ryosuke Amano, Bunzo Nakata, Sadaaki Yamazoe, Go Ohira, Kotaro Miura, Naoki Kametani, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa and Masaichi Ohira |
| Funding Agency and Grant Number |
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| Corresponding Author |
Kenjiro Kimura, MD, PhD, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan. kenjiro@med.osaka-cu.ac.jp |
| Key Words |
doublecortin and CaM kinase-like-1; Pancreatic cancer; Epithelial mesenchymal transition; Cancer stem cell; Prognostic factor |
| Core Tip |
Doublecortin and CaM kinase-like-1 (DCLK1) is a microtubule - associated kinase and has recently attracted much attention as an important cancer stem cell marker. DCLK1 expression is correlated with aggressiveness in various cancers. However, there have been few investigations correlating DCLK1 expression with survival in pancreatic ductal adenocarcinoma (PDAC). PDAC patients with DCLK1-positive tumors had significantly shorter survival times than those with DCLK1-negative tumors. DCLK1 expression was an independent prognostic factor by multivariate survival analysis. Furthermore, DCLK1-positive expression was correlated to EpCAM expression and triple-positive expression of CD44/CD24/EpCAM. These findings suggest DCLK1 may have a crucial prognostic role in acquisition of stemness. |
| Publish Date |
2017-08-19 11:33 |
| Citation |
Nishio K, Kimura K, Amano R, Nakata B, Yamazoe S, Ohira G, Miura K, Kametani N, Tanaka H, Muguruma K, Hirakawa K, Ohira M. Doublecortin and CaM kinase-like-1 as an independent poor prognostic factor for resected pancreatic carcinoma. World J Gastroenterol 2017; 23(31): 5764-5772 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i31/5764.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i31.5764 |
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