Publication Name	World Journal of Gastroenterology
Manuscript ID	34172
Country	Mexico

Received	2017-04-01 08:38
Peer-Review Started	2017-04-09 17:05
To Make the First Decision	2017-04-26 08:47
Return for Revision	2017-04-28 12:00
Revised	2017-05-27 03:13
Second Decision	2017-07-21 07:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-24 08:03
Articles in Press	2017-07-24 08:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-09-25 12:25
Publish the Manuscript Online	2017-09-28 10:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Road to stemness in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Teresita NJ Flores-Téllez, Saúl Villa-Treviño and Carolina Piña-Vázquez
Funding Agency and Grant Number	Funding Agency Grant Number CONACyT Mexico grant 2015-01-599
Corresponding Author	Carolina Piña-Vázquez, PhD, Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Av. IPN No. 2508 Col., Ciudad de México CP 07360, Mexico. caropv@cell.cinvestav.mx
Key Words	Cancer stem cell; Liver progenitor cell; Liver stem progenitor cell; Stemness; Plasticity; Cancer cell of origin; Cancer stem cells subpopulations
Core Tip	In agreement with their dominant role in liver regeneration, mature hepatocytes are emerging as the cell of origin of hepatocellular carcinoma. The relationship between the cancer cell of origin (CCO) and hepatic cancer stem cell is unknown. There is a dynamic interconversion among different cancer stem cells (CSCs), and between CSC and non-CSCs. Because of that, CSC-state is currently defined as a description of a highly adaptable and dynamic intrinsic property of tumor cells, instead of a static subpopulation of a tumor. This CSC heterogeneity and dynamism makes them out reach from therapeutic protocols directed to a single target.
Publish Date	2017-09-28 10:01
Citation	Flores-Téllez TNJ, Villa-Treviño S, Piña-Vázquez C. Road to stemness in hepatocellular carcinoma. World J Gastroenterol 2017; 23(37): 6750-6776
URL	http://www.wjgnet.com/1007-9327/full/v23/i37/6750.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i37.6750

Full Article (PDF)	WJG-23-6750.pdf
Full Article (Word)	WJG-23-6750.doc
Manuscript File	34172-Review.docx
Answering Reviewers	34172-Answering reviewers.pdf
Audio Core Tip	34172-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	34172-Conflict-of-interest statement.pdf
Copyright License Agreement	34172-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34172-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	34172-Language certificate.pdf
Supplementary Material	34172-Supplementary material.pdf
Peer-review Report	34172-Peer-review(s).pdf
Scientific Misconduct Check	34172-Scientific misconduct check.pdf
Scientific Editor Work List	34172-Scientific editor work list.pdf