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Articles Published Processes
12/7/2017 9:09:00 AM | Browse: 1004 | Download: 922
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Received |
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2017-04-07 08:49 |
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Peer-Review Started |
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2017-04-10 16:00 |
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To Make the First Decision |
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2017-07-10 00:50 |
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Return for Revision |
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2017-07-18 05:28 |
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Revised |
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2017-07-20 18:55 |
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Second Decision |
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2017-08-25 07:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-09-04 03:58 |
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Articles in Press |
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2017-09-04 03:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-11-28 04:19 |
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Publish the Manuscript Online |
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2017-12-07 09:09 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non- Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Field of Vision |
| Article Title |
Gut-brain crosstalk regulates craving for fatty food
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rajendra Raghow |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Rajendra Raghow, PhD, Professor, Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, United States. rraghow@uthsc.edu |
| Key Words |
Roux-en-Y gastric bypass surgery; Dietary lipids; Dopamine D1 receptors; Peroxisome proliferator activated receptor-alpha; Oleoylethanolamide |
| Core Tip |
The mechanisms underlying a massive and sustained body weight loss after gastric bypass surgery remain poorly understood. Hankir et al describe how a fat-satiety signaling pathway that was greatly blunted in obese rats could be restored by Roux-en-Y gastric bypass (RYGB) surgery. The authors have demonstrated that RYGB rats on high fat diet (HFD) elicited an increased production of oleoylethanolamide (OEA) and activation of PPAR that led to a surge in dopamine release and activation of D1 in the dorsal striatum. The enhanced dopamine neurotransmission evoked by OEA was obligatorily dependent on intact vagus nerve that had no effect on the production of OEA in the small intestine. The heightened dopamine neurotransmission in the midbrain of RYGB rats was linked to their decreased preference for HFD. These elegant studies have provided a compelling mechanism by which RYGB surgery led to altered gut-brain communication to modify the reward circuitry involved in food preference and obesity. These observations have important clinical implications for the amelioration obesity and its pathological consequences. |
| Publish Date |
2017-12-07 09:09 |
| Citation |
Raghow R. Gut-brain crosstalk regulates craving for fatty food. World J Diabetes 2017; 8(12): 484-488 |
| URL |
http://www.wjgnet.com/1948-9358/full/v8/i12/484.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v8.i12.484 |
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