Publication Name	World Journal of Gastroenterology
Manuscript ID	34256
Country	South Korea

Received	2017-04-12 10:09
Peer-Review Started	2017-04-20 09:02
To Make the First Decision	2017-05-12 08:47
Return for Revision	2017-05-16 02:41
Revised	2017-05-29 10:18
Second Decision	2017-06-27 01:56
Accepted by Journal Editor-in-Chief	2017-06-27 06:39
Accepted by Company Editor-in-Chief	2017-07-04 06:03
Articles in Press	2017-07-04 06:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-07-09 02:56
Typeset the Manuscript	2017-07-19 02:34
Publish the Manuscript Online	2017-07-28 08:16

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients
Manuscript Source	Invited Manuscript
All Author List	Jung Won Park, Jin Ha Lee, Ye Hyun Park, Soo Jung Park, Jae Hee Cheon, Won Ho Kim and Tae Il Kim
ORCID	Author(s) ORCID Number Jung Won Park http://orcid.org/0000-0003-1861-3975 Jin Ha Lee http://orcid.org/0000-0003-2732-1050 Soo Jung Park http://orcid.org/0000-0003-0699-6809 Jae Hee Cheon http://orcid.org/0000-0002-2282-8904 Won Ho Kim http://orcid.org/0000-0002-3711-9916
Funding Agency and Grant Number	Funding Agency Grant Number Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education 2013R1A1A2010733 National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea 1631020
Corresponding Author	Tae Il Kim, MD, PhD, Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. taeilkim@yuhs.ac
Key Words	Colorectal cancer; Metformin; Survival; Sex
Core Tip	Evidence from previous studies has identified the anti-tumor effect of metformin; however, the factors related to effectiveness of metformin in diabetic colorectal cancer (CRC) patients have not been identified yet. Identifying subgroup patients who benefit from metformin treatment is important for future clinical application of metformin, and a strong sex-dependent difference of metformin effect in advanced CRC patients has been identified in this present study.
Publish Date	2017-07-28 08:16
Citation	Park JW, Lee JH, Park YH, Park SJ, Cheon JH, Kim WH, Kim TI. Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients. World J Gastroenterol 2017; 23(28): 5196-5205
URL	http://www.wjgnet.com/1007-9327/full/v23/i28/5196.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i28.5196

Full Article (PDF)	WJG-23-5196.pdf
Full Article (Word)	WJG-23-5196.doc
Manuscript File	34256-Review.docx
Answering Reviewers	34256-Answering reviewers.pdf
Audio Core Tip	34256-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	34256-Conflict-of-interest statement.pdf
Copyright License Agreement	34256-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34256-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	34256-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	34256-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	34256-Language certificate.pdf
Peer-review Report	34256-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	34256-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	34256-Scientific misconduct check.pdf
Scientific Editor Work List	34256-Scientific editor work list.pdf