Publication Name	World Journal of Gastroenterology
Manuscript ID	34297
Country	China

Received	2017-04-24 09:18
Peer-Review Started	2017-04-25 16:45
To Make the First Decision	2017-06-01 02:35
Return for Revision	2017-06-05 03:07
Revised	2017-06-20 21:06
Second Decision	2017-06-27 06:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-04 05:57
Articles in Press	2017-07-04 05:57
Publication Fee Transferred	2017-07-07 05:02
Edit the Manuscript by Language Editor	2017-07-18 23:02
Typeset the Manuscript	2017-08-03 11:00
Publish the Manuscript Online	2017-08-14 04:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Integrative & Complementary Medicine
Manuscript Type	Basic Study
Article Title	Yangzheng Sanjie decoction regulates proliferation and apoptosis of gastric cancer cells by enhancing let-7a expression
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Xia Deng, Ya-Ya Yu, Ao-Qiang Zhou, Jing-Li Zhu, Li-Na Luo, Wan-Qun Chen, Ling Hu and Geng-Xin Chen
ORCID	Author(s) ORCID Number Hai-Xia Deng http://orcid.org/0000-0002-9373-2379 Ya-Ya Yu http://orcid.org/0000-0001-8287-7401 Ao-Qiang Zhou http://orcid.org/0000-0002-5594-4303 Jing-Li Zhu http://orcid.org/0000-0001-5514-0906 Li-Na Luo http://orcid.org/0000-0001-5905-2882 Wan-Qun Chen http://orcid.org/0000-0002-1126-2968 Ling Hu http://orcid.org/0000-0003-3104-8050 Geng-Xin Chen http://orcid.org/0000-0003-1475-1078
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81273735 National Natural Science Foundation of China 81373563 Science and Technology Planning Project of Guangdong Province 2016A020215135 Science and Technology Planning Project of Guangdong Province 2013B021800169 Traditional Chinese Medicine Science and Technology Research Projects of Guangdong Provincial Hospital of Chinese Medicine, China YN2014ZH05
Corresponding Author	Geng-Xin Chen, MD, PhD, Professor, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou 510120, Guangdong Province, China. gxchen@gzucm.edu.cn
Key Words	Gastric cancer; Let-7a; c-Myc; Proliferation; Apoptosis; Yangzheng Sanjie decoction
Core Tip	Let-7a reduction plays an important role in gastric tumourigenesis through the derepression of c-Myc expression. Our data demonstrate that Yangzheng Sanjie decoction (YZSJD) inhibits proli­feration and induces apoptosis in gastric cancer (GC) cells by regulating the aberrant expression of let-7a and c-Myc. These findings provide new evidence that YZSJD has therapeutic potential in GC treatment and that miRNA regulation may be a novel molecular mechanism through which Chinese herbal medicine exhibits anti-cancer activity.
Publish Date	2017-08-14 04:00
Citation	Deng HX, Yu YY, Zhou AQ, Zhu JL, Luo LN, Chen WQ, Hu L, Chen GX. Yangzheng Sanjie decoction regulates proliferation and apoptosis of gastric cancer cells by enhancing let-7a expression. World J Gastroenterol 2017; 23(30): 5538-5548
URL	http://www.wjgnet.com/1007-9327/full/v23/i30/5538.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i30.5538

Full Article (PDF)	WJG-23-5538.pdf
Full Article (Word)	WJG-23-5538.doc
Manuscript File	34297-Review.doc
Answering Reviewers	34297-Answering reviewers.pdf
Audio Core Tip	34297-Audio core tip.mp3
Biostatistics Review Certificate	34297-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	34297-Conflict-of-interest statement.pdf
Copyright License Agreement	34297-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34297-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	34297-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	34297-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	34297-Language certificate.pdf
Peer-review Report	34297-Peer-review(s).pdf
Scientific Misconduct Check	34297-Scientific misconduct check.pdf
Scientific Editor Work List	34297-Scientific editor work list.pdf