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Articles Published Processes
8/14/2017 4:00:08 AM | Browse: 1409 | Download: 3060
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Received |
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2017-04-24 09:18 |
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Peer-Review Started |
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2017-04-25 16:45 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2017-06-05 03:07 |
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Revised |
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2017-06-20 21:06 |
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Publication Fee Transferred |
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2017-07-07 05:02 |
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Second Decision by Editor |
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2017-06-27 06:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-07-04 05:57 |
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Articles in Press |
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2017-07-04 05:57 |
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Edit the Manuscript by Language Editor |
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2017-07-18 23:02 |
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Typeset the Manuscript |
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2017-08-03 11:00 |
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Publish the Manuscript Online |
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2017-08-14 04:00 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Yangzheng Sanjie decoction regulates proliferation and apoptosis of gastric cancer cells by enhancing let-7a expression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Xia Deng, Ya-Ya Yu, Ao-Qiang Zhou, Jing-Li Zhu, Li-Na Luo, Wan-Qun Chen, Ling Hu and Geng-Xin Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81273735 |
| National Natural Science Foundation of China |
81373563 |
| Science and Technology Planning Project of Guangdong Province |
2016A020215135 |
| Science and Technology Planning Project of Guangdong Province |
2013B021800169 |
| Traditional Chinese Medicine Science and Technology Research Projects of Guangdong Provincial Hospital of Chinese Medicine, China |
YN2014ZH05 |
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| Corresponding Author |
Geng-Xin Chen, MD, PhD, Professor, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou 510120, Guangdong Province, China. gxchen@gzucm.edu.cn |
| Key Words |
Gastric cancer; Let-7a; c-Myc; Proliferation; Apoptosis; Yangzheng Sanjie decoction |
| Core Tip |
Let-7a reduction plays an important role in gastric tumourigenesis through the derepression of c-Myc expression. Our data demonstrate that Yangzheng Sanjie decoction (YZSJD) inhibits proliferation and induces apoptosis in gastric cancer (GC) cells by regulating the aberrant expression of let-7a and c-Myc. These findings provide new evidence that YZSJD has therapeutic potential in GC treatment and that miRNA regulation may be a novel molecular mechanism through which Chinese herbal medicine exhibits anti-cancer activity. |
| Publish Date |
2017-08-14 04:00 |
| Citation |
Deng HX, Yu YY, Zhou AQ, Zhu JL, Luo LN, Chen WQ, Hu L, Chen GX. Yangzheng Sanjie decoction regulates proliferation and apoptosis of gastric cancer cells by enhancing let-7a expression. World J Gastroenterol 2017; 23(30): 5538-5548 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i30/5538.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i30.5538 |
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