| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Cintia Folgueira, Silvia Barja-Fernandez, Laura Prado, Omar Al-massadi, Cecilia Castelao, Veronica Pena-Leon, Patricia Gonzalez-Saenz, Javier Baltar, Ivan Baamonde, Rosaura Leis, Carlos Dieguez, Uberto Pagotto, Felipe F Casanueva, Sulay A Tovar, Ruben Nogueiras and Luisa M Seoane |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Instituto de Salud Carlos III, FEDER |
PI15/ 01272 |
| Fondo de Investigaciones Sanitarias |
I3SNS-SERGAS/ISCIII |
| Centro de Investigacion Biomedica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn) is a iniciative of the Instituto de Salud Carlos III (ISCIII) of Spain |
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| Corresponding Author |
Luisa M Seoane, PhD, Grupo Fisiopatología Endocrina, Laboratorio 14, Instituto de Investigación Sanitaria, Complexo Hospitalario Universitario de Santiago, Travesía da Choupana s/n, Santiago de Compostela 15706, Spain. luisamaria.seoane@usc.es |
| Key Words |
UCB2/nesfatin-1; Stomach; Food intake; Cannabinoid receptor 1; mTOR |
| Core Tip |
The peripheral pharmacological blockade of the cannabinoid receptor 1 (CB1) induces a decrease in food intake in rats by stimulating the gastric secretion, and consequently the circulating levels, of the anorexigenic peptide Nucb2/nesfatin-1. The present data show that gastric CB1 receptors modulate Nucb2/Nesfatin-1 production in the stomach at the intracellular level, which is mediated by the mTOR pathway. |
| Publish Date |
2017-09-21 07:51 |
| Citation |
Folgueira C, Barja-Fernandez S, Prado L, Al-Massadi O, Castelao C, Pena-Leon V, Gonzalez-Saenz P, Baltar J, Baamonde I, Leis R, Dieguez C, Pagotto U, Casanueva FF, Tovar SA, Nogueiras R, Seoane LM. Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway. World J Gastroenterol 2017; 23(35): 6403-6411 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i35/6403.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i35.6403 |
