Publication Name	World Journal of Gastroenterology
Manuscript ID	34400
Country	Poland

Received	2017-04-27 09:58
Peer-Review Started	2017-04-27 18:25
To Make the First Decision	2017-06-08 00:32
Return for Revision	2017-06-13 03:27
Revised	2017-07-19 08:58
Second Decision	2017-07-24 01:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-08-02 07:02
Articles in Press	2017-08-02 07:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-17 02:32
Publish the Manuscript Online	2017-09-07 08:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Neurosciences
Manuscript Type	Basic Study
Article Title	Changes in expression of inhibitory substances in the intramural neurons of the stomach following streptozotocin- induced diabetes in the pig
Manuscript Source	Invited Manuscript
All Author List	Michal Bulc, Katarzyna Palus, Lukasz Zielonka, Magdalena Gajecka and Jaroslaw Calka
ORCID	Author(s) ORCID Number Michal Bulc http://orcid.org/0000-0002-1402-5423 Katarzyna Palus http://orcid.org/0000-0002-7593-9552 Lukasz Zielonka http://orcid.org/0000-0003-0983-5592 Magdalena Gajecka http://orcid.org/0000-0001-5507-5091 Jaroslaw Calka http://orcid.org/0000-0003-4679-5737
Funding Agency and Grant Number	Funding Agency Grant Number A statutory Grant 528-0523.0802 KNOW (Leading National Research Centre) Scientific Consortium “Healthy Animal-Safe Food”, decision of Ministry of Science and Higher Education 05-1/KNOW2/2015
Corresponding Author	Michal Bulc, DVM, Associate Professor, Department of Clinical Physiology Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Str. 13, Olsztyn 10-719, Poland. michal.bulc@uwm.edu.pl
Key Words	Immunohistochemistry; Inhibitory neurons; Streptozotocin; Hyperglycemia; Pig
Core Tip	Our results revealed the neuronal plasticity of enteric neurons within porcine stomach in response to chronic hyperglycemia. We used the pig as a model for human gastrointestinal disorders occurring in people with diabetes. Our study highlights the important role of the enteric nervous system in response to high glucose serum level. We observed a substantial increase in the expression of nitric oxide, galanin and vasoactive intestinal peptide inside the enteric neurons. Since all of the investigated molecules have inhibitory properties, they may be involved in the impairment of the motor function of the stomach occurring in people with long-term diabetes.
Publish Date	2017-09-07 08:51
Citation	Bulc M, Palus K, Zielonka L, Gajęcka M, Całka J. Changes in expression of inhibitory substances in the intramural neurons of the stomach following streptozotocin- induced diabetes in the pig. World J Gastroenterol 2017; 23(33): 6088-6099
URL	http://www.wjgnet.com/1007-9327/full/v23/i33/6088.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i33.6088

Full Article (PDF)	WJG-23-6088.pdf
Full Article (Word)	WJG-23-6088.doc
Manuscript File	34400-Review.docx
Answering Reviewers	34400-Answering reviewers.pdf
Audio Core Tip	34400-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	34400-Conflict-of-interest statement.pdf
Copyright License Agreement	34400-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34400-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	34400-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	34400-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	34400-Language certificate.pdf
Peer-review Report	34400-Peer-review(s).pdf
Scientific Misconduct Check	34400-Scientific misconduct check.pdf
Scientific Editor Work List	34400-Scientific editor work list.pdf