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Articles Published Processes
11/20/2017 4:03:35 AM | Browse: 1131 | Download: 1450
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Received |
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2017-04-24 10:38 |
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Peer-Review Started |
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2017-04-25 17:16 |
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To Make the First Decision |
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2017-06-22 05:59 |
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Return for Revision |
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2017-06-27 08:49 |
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Revised |
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2017-09-01 08:43 |
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Second Decision |
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2017-11-01 07:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-01 21:16 |
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Articles in Press |
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2017-11-01 21:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-11-08 08:47 |
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Publish the Manuscript Online |
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2017-11-20 04:03 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Minireviews |
| Article Title |
Functional interaction of endoplasmic reticulum stress and hepatitis B virus in the pathogenesis of liver diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
So Young Kim, Yi Yi Kyaw and JaeHun Cheong |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of South Korea |
NRF-2009-0093195 |
| Basic Science Research Program through the NRF |
NRF-2013R1A1A2057634 |
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| Corresponding Author |
JaeHun Cheong, PhD, Department of Molecular Biology, Pusan National University, Busan 609-735, South Korea. molecule85@pusan.ac.kr |
| Key Words |
Liver disease; Hepatitis B virus; Hepatitis B virus X protein; Endoplasmic reticulum stress; Unfolded protein response |
| Core Tip |
Endoplasmic reticulum (ER) is the major site of protein folding and calcium storage. Beside the role of ER in protein homeostasis, it controls the cholesterol production and lipid-membrane biosynthesis as well as surviving and cell death signaling mechanisms in the cell. It is well-documented that abnormal metabolic regulation induces adverse effects in liver disorders, such as non-alcoholic steatosis hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma which are associated with hepatitis B virus (HBV) infection. Recent animal model and human studies have showed ER stress as an emerging factors involved in the development of metabolic and liver diseases. In this review, we will summarize the crucial effects of ER stress response in the pathogenesis of HBV-induced liver diseases. |
| Publish Date |
2017-11-20 04:03 |
| Citation |
Kim SY, Kyaw YY, Cheong J. Functional interaction of endoplasmic reticulum stress and hepatitis B virus in the pathogenesis of liver diseases. World J Gastroenterol 2017; 23(43): 7657-7665 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i43/7657.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i43.7657 |
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