Publication Name	World Journal of Hepatology
Manuscript ID	34540
Country	Sweden

Received	2017-05-31 02:06
Peer-Review Started	2017-06-01 09:51
To Make the First Decision	2017-07-10 00:49
Return for Revision	2017-07-20 02:53
Revised	2017-08-10 14:43
Second Decision	2017-09-14 07:08
Accepted by Journal Editor-in-Chief	2017-09-14 09:05
Accepted by Executive Editor-in-Chief	2017-10-16 06:24
Articles in Press	2017-10-16 06:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-28 04:21
Publish the Manuscript Online	2017-12-05 01:55

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http:///creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury
Manuscript Source	Unsolicited Manuscript
All Author List	Rim Jawad, Melroy D'souza, Lisa Arodin Selenius, Marita Wallenberg Lundgren, Olof Danielsson, Greg Nowak, Mikael Björnstedt and Bengt Isaksson
ORCID	Author(s) ORCID Number Rim Jawad http://orcid.org/0000-0002-4216-0913 Melroy D'souza http://orcid.org/0000-0002-6798-8960 Lisa Arodin Selenius http://orcid.org/0000-0002-1148-5897 Marita Wallenberg Lundgren http://orcid.org/0000-0003-3256-7063 Olof Danielsson http://orcid.org/0000-0002-2558-2401 Greg Nowak http://orcid.org/0000-0001-8766-8860 Mikael Björnstedt http://orcid.org/0000-0003-2831-3837 Bengt Isaksson http://orcid.org/0000-0002-7518-7127
Funding Agency and Grant Number	Funding Agency Grant Number Cancerfonden Cancer och Allergifonden Radiumhemmets forskningsfonder ALF Jochnick foundation
Corresponding Author	Melroy D'souza, Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141-86, Sweden. melroy.dsouza@karolinska.se
Key Words	Hepatic ischemia-reperfusion injury; Ischemia reperfusion injury; Warm ischemia-reperfusion injury; Glutaredoxins; Thioredoxins; Electron microscopy; Oxidative stress; Portal triad clamping
Core Tip	The complex mechanisms of warm Ischemia reperfusion (I/R) injury in the liver are diverse and have been widely studied but poorly understood. This study aims to investigate the ultrastructural changes at warm I/R injury induced by portal triad clamping. The effects were mainly borne by the liver sinusoidal endothelial cells (LSEC) which detached from the sinusoidal wall after ischemia. Interestingly we found that the LSECs reattached after reperfusion. Hepatocytes were unaffected except for the appearance of crystalline inclusions in the mitochondria. Investigation of redox related proteins showed no changes within our time frame.
Publish Date	2017-12-05 01:55
Citation	Jawad R, D’souza M, Selenius LA, Lundgren MW, Danielsson O, Nowak G, Björnstedt M, Isaksson B. Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury. World J Hepatol 2017; 9(34): 1261-1269
URL	http://www.wjgnet.com/1948-5182/full/v9/i34/1261.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i34.1261

Full Article (PDF)	WJH-9-1261.pdf
Full Article (Word)	WJH-9-1261.doc
Manuscript File	34540-Review.docx
Answering Reviewers	34540-Answering reviewers.pdf
Audio Core Tip	34540-Audio core tip.mp3
Biostatistics Review Certificate	34540-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	34540-Conflict-of-interest statement.pdf
Copyright License Agreement	34540-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34540-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	34540-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	34540_Language certificate for manuscript.pdf
Supplementary Material	34540-Supplementary material.pdf
Peer-review Report	34540-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	34540-Journal editor-in-chief review report.pdf
Scientific Editor Work List	34540-Scientific editor work list.pdf