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12/27/2017 11:08:07 AM | Browse: 447 | Download: 342
Publication Name World Journal of Gastroenterology
Manuscript ID 34554
Country/Territory Croatia
2017-06-05 01:23
Peer-Review Started
2017-06-06 09:01
To Make the First Decision
2017-06-22 05:59
Return for Revision
2017-06-27 09:05
2017-10-31 23:41
Second Decision
2017-11-27 10:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-27 20:34
Articles in Press
2017-11-27 20:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-12-05 09:04
Publish the Manuscript Online
2017-12-27 11:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pharmacology and Pharmacy
Manuscript Type Basic Study
Article Title Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights
Manuscript Source Invited Manuscript
All Author List Antonija Duzel, Josipa Vlainic, Marko Antunovic, Dominik Malekinusic, Borna Vrdoljak, Mariam Samara, Slaven Gojkovic, Ivan Krezic, Tinka Vidovic, Zdenko Bilic, Mario Knezevic, Marko Sever, Nermin Lojo, Antonio Kokot, Marijan Kolovrat, Domagoj Drmic, Jaksa Vukojevic, Tamara Kralj, Katarina Kasnik, Marko Siroglavic, Sven Seiwerth and Predrag Sikiric
Author(s) ORCID Number
Antonija Duzel http://orcid.org/0000-0001-6784-5823
Josipa Vlainic http://orcid.org/0000-0002-3113-420X
Marko Antunovic http://orcid.org/0000-0002-3801-5481
Dominik Malekinusic http://orcid.org/0000-0001-6258-5647
Borna Vrdoljak http://orcid.org/0000-0003-2306-8799
Mariam Samara http://orcid.org/0000-0003-2384-273X
Slaven Gojkovic http://orcid.org/0000-0003-4020-326X
Ivan Krezic http://orcid.org/0000-0001-7994-5645
Tinka Vidovic http://orcid.org/0000-0003-0092-9365
Zdenko Bilic http://orcid.org/0000-0003-2503-7179
Mario Knezevic http://orcid.org/0000-0001-6448-7274
Marko Sever http://orcid.org/0000-0002-2599-6014
Nermin Lojo http://orcid.org/0000-0003-1981-711X
Antonio Kokot http://orcid.org/0000-0002-4836-7536
Marijan Kolovrat http://orcid.org/0000-0002-2065-0049
Domagoj Drmic http://orcid.org/0000-0002-1081-7175
Jaksa Vukojevic http://orcid.org/0000-0003-4215-6743
Tamara Kralj http://orcid.org/0000-0002-3880-507X
Katarina Kasnik http://orcid.org/0000-0001-8110-9849
Marko Siroglavic http://orcid.org/0000-0003-2582-747X
Sven Seiwerth http://orcid.org/0000-0002-5894-419X
Predrag Sikiric http://orcid.org/0000-0002-7952-2252
Funding Agency and Grant Number
Corresponding author Predrag Sikiric, MD, PhD, Professor, Department of Pharmacology, School of Medicine, University of Zagreb, Salata 11, Zagreb 10000, Croatia. sikiric@mef.hr
Keywords Ischemic colitis; Blood flow rescue; Collaterals; BPC 157; L-NAME; L-arginine; Oxidative stress; NO; Rats
Core Tip We rescued rat ischemic colitis. The gastric pentadecapeptide BPC 157, which has been used in clinical trials for ulcerative colitis, exerted rapid cytoprotective endothelium rescue against the disabled left colic artery and vein after blood deprivation via two ligations and during reperfusion (ligations removed). By bypassing obstructions, quickly rescuing blood supply, rapidly activating collaterals, and restoring arcade interconnections, as a new integrative beneficial effect, BPC 157 prevented the occurrence of pale lesions without mucosal folds and normalized the levels of NO and MDA, two oxidative stress markers, in tissues. BPC 157 showed effectiveness over the NO-system background, immobilized (L-NAME+L-arginine), (over)stimulated (L-arginine) or blocked (L-NAME). Likewise, later application of BPC 157 in a bath treatment to rats with pertinently obstructed vessels that underwent additional colon obstruction for three days produced a similar beneficial effect.
Publish Date 2017-12-27 11:08
Citation Duzel A, Vlainic J, Antunovic M, Malekinusic D, Vrdoljak B, Samara M, Gojkovic S, Krezic I, Vidovic T, Bilic Z, Knezevic M, Sever M, Lojo N, Kokot A, Kolovrat M, Drmic D, Vukojevic J, Kralj T, Kasnik K, Siroglavic M, Seiwerth S, Sikiric P. Stable gastric pentadecapeptide BPC 157 in treatment of colitis and ischemia and reperfusion in rats: New insights. World J Gastroenterol 2017; 23(48): 8465-8488
Url http://www.wjgnet.com/1007-9327/full/v23/i48/8465.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i48.8465
Full Article (PDF) WJG-23-8465.pdf
Full Article (Word) WJG-23-8465.doc
Manuscript File 34554-Review.docx
Answering Reviewers 34554-Answering reviewers.pdf
Audio Core Tip 34554-Audio core tip.mp3
Biostatistics Review Certificate 34554-Biostatistics-Review-Certificate-revision.docx
Conflict-of-Interest Disclosure Form 34554-Conflict-of-interest statement.pdf
Copyright License Agreement 34554-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 34554-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 34554-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 34554-Language certificate.pdf
Supplementary Material 34554-Supplementary-Material-revision.docx
Peer-review Report 34554-Peer-review(s).pdf
Scientific Misconduct Check 34554-Scientific misconduct check.pdf
Scientific Editor Work List 34554-Scientific editor work list.pdf