Publication Name	World Journal of Gastroenterology
Manuscript ID	34562
Country	China

Received	2017-05-08 09:14
Peer-Review Started	2017-05-08 16:46
To Make the First Decision	2017-06-22 01:02
Return for Revision	2017-06-23 09:11
Revised	2017-07-05 16:17
Second Decision	2017-08-01 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-08-08 17:02
Articles in Press	2017-08-08 17:02
Publication Fee Transferred	2017-08-10 14:54
Edit the Manuscript by Language Editor	2017-08-21 00:44
Typeset the Manuscript	2017-09-04 11:44
Publish the Manuscript Online	2017-09-14 03:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected b-y an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is prope-rly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Chemistry, Medicinal
Manuscript Type	Basic Study
Article Title	Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and HepG2 hepatoma cells
Manuscript Source	Unsolicited Manuscript
All Author List	Cai-Jie Lu, Yi-Feng He, Wei-Zhuang Yuan, Li-Jun Xiang, Jian Zhang, Yan-Rui Liang, Juan Duan, Yun-He He and Ming-Yi Li
ORCID	Author(s) ORCID Number Cai-Jie Lu http://orcid.org/0000-0003-2718-2767 Yi-Feng He http://orcid.org/0000-0001-7130-0308 Wei-Zhuang Yuan http://orcid.org/0000-0002-0450-4690 Li-Jun Xiang http://orcid.org/0000-0001-5310-6245 Jian Zhang http://orcid.org/0000-0002-9318-0228 Yan-Rui Liang http://orcid.org/0000-0002-5094-3790 Juan Duan http://orcid.org/0000-0002-5454-3727 Yun-He He http://orcid.org/0000-0001-8222-2755 Ming-Yi Li http://orcid.org/0000-0001-6317-9368
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Funds 81041099 Natural Science Foundation of Guangdong Province S2011010003750
Corresponding Author	Ming-Yi Li, PhD, Professor, Laboratory of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, No. 57 South Renmin Road, Zhanjiang 524001, Guangdong Province, China. limingyi62@163.com
Key Words	Dihydromyricetin; Apoptosis; Hepatocellular carcinoma; Notch1
Core Tip	The novel findings of this study are that Notch1 is highly expressed in tumor cells with higher degrees of malignancy and proliferative activity, Notch1 is involved in the development of hepatocellular carcinoma (HCC) and may serve as a potential diagnostic marker for HCC. Dihydromyricetin can strongly induce apoptosis of the hepatic cancer cell lines QGY7701 and HepG2 by downregulating the expression of Notch1.
Publish Date	2017-09-14 03:13
Citation	Lu CJ, He YF, Yuan WZ, Xiang LJ, Zhang J, Liang YR, Duan J, He YH, Li MY. Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and HepG2 hepatoma cells. World J Gastroenterol 2017; 23(34): 6242-6251
URL	http://www.wjgnet.com/1007-9327/full/v23/i34/6242.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i34.6242

Full Article (PDF)	WJG-23-6242.pdf
Full Article (Word)	WJG-23-6242.doc
Manuscript File	34562-Review.docx
Answering Reviewers	34562-Answering reviewers.pdf
Audio Core Tip	34562-Audio core tip .mp3
Biostatistics Review Certificate	34562-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	34562-Conflict-of-interest statement.pdf
Copyright License Agreement	34562-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34562-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	34562-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	34562-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	34562-Language certificate.pdf
Peer-review Report	34562-Peer-review(s).pdf
Scientific Misconduct Check	34562-Scientific misconduct check.pdf
Scientific Editor Work List	34562-Scientific editor work listt.pdf