Publication Name	World Journal of Biological Chemistry
Manuscript ID	3458
Country	Italy

Received	2013-05-01 13:41
Peer-Review Started	2013-05-03 13:30
To Make the First Decision	2013-06-09 10:13
Return for Revision	2013-06-18 14:22
Revised	2013-07-03 22:50
Second Decision	2013-07-24 13:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-07-25 04:01
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-13 14:46
Publish the Manuscript Online	2013-08-15 17:51

ISSN	1949-8454 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Autobiography
Article Title	Potent trophic activity of spermidine supramolecular complexes in in vitro models
Manuscript Source	Invited Manuscript
All Author List	Carlo A Ghisalberti, Alberto Morisetti, Alessandro Bestetti and Gaetano Cairo
Funding Agency and Grant Number	Funding Agency Grant Number Italian Ministry of Education
Corresponding Author	Gaetano Cairo, Professor, Department of Biomedical Science for Health, University of Milano, Via Mangiagalli 31, 20133 Milano, Italy. gaetano.cairo@unimi.it
Key Words	Polyamines; Spermidine; Growth; Supramolecular complexes; Vaginal epithelium; Ki-67
Core Tip	Previous in vitro studies showed that spermidine may have different, or even opposite, effects on cell survival, leading to either proliferation or apoptosis depending on a variety of factors. We showed that the inclusion of spermidine in supramolecular complexes with various polymers optimized its use for regenerative purposes. Spermidine-supramolecular complexes stimulated cell proliferation but did not cause significant alterations to vaginal tissue integrity. These results suggest that growth pathways in senescent or damaged tissues may be activated by the controlled release of spermidine from spermidine-supramolecular complexes to provide a faster recovery.
Publish Date	2013-08-15 17:51
Citation	Ghisalberti CA, Morisetti A, Bestetti A, Cairo G. Potent trophic activity of spermidine supramolecular complexes in in vitro models. World J Biol Chem 2013; 4(3): 71-78
URL	http://www.wjgnet.com/1949-8454/full/v4/i3/71.htm
DOI	http://dx.doi.org/10.4331/wjbc.v4.i3.71

Full Article (PDF)	WJBC-4-71.pdf
Manuscript File	3458-Review.doc
Answering Reviewers	3458-Answering reviewers.pdf
Copyright License Agreement	3458-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3458-Language certificate.pdf
Peer-review Report	3458-Peer review.pdf
Scientific Editor Work List	3458-Scientific editor work list.doc