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9/20/2017 1:02:37 AM | Browse: 964 | Download: 1349
Publication Name World Journal of Stem Cells
Manuscript ID 34591
Country/Territory Australia
Received
2017-05-09 09:22
Peer-Review Started
2017-05-10 08:43
To Make the First Decision
2017-06-14 00:47
Return for Revision
2017-06-16 05:58
Revised
2017-06-29 07:15
Second Decision
2017-07-06 09:14
Accepted by Journal Editor-in-Chief
2017-07-06 10:54
Accepted by Company Editor-in-Chief
2017-07-17 06:12
Articles in Press
2017-07-17 06:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-13 06:03
Publish the Manuscript Online
2017-09-20 01:02
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity
Manuscript Source Invited Manuscript
All Author List Aparna Jayachandran, Ritu Shrestha, Bijay Dhungel, I-Tao Huang, Marianna Yumi Kawashima Vasconcelos, Brian J Morrison, Charmaine A Ramlogan-Steel and Jason C Steel
ORCID
Author(s) ORCID Number
Aparna Jayachandran http://orcid.org/0000-0002-6283-1550
Ritu Shrestha http://orcid.org/0000-0002-0276-3090
Bijay Dhungel http://orcid.org/0000-0001-5130-5224
I-Tao Huang http://orcid.org/0000-0002-3536-1872
Marianna Yumi Kawashima Vasconcelos http://orcid.org/0000-0002-1384-649X
Brian J Morrison http://orcid.org/0000-0003-4649-6999
Charmaine A Ramlogan-Steel http://orcid.org/0000-0002-6810-4602
Jason C Steel http://orcid.org/0000-0003-3608-7542
Funding Agency and Grant Number
Funding Agency Grant Number
Gallipoli Medical Research Foundation, Australia 016092
Cyril Gilbert Foundation, Australia 017348
Corresponding Author Jason C Steel, PhD, Liver Cancer Unit, the University of Queensland School of Medicine and the Gallipoli Medical Research Institute, Greenslopes Private Hospital, Newdegate Street, QLD 4120, Brisbane, Australia. j.steel2@uq.edu.au
Key Words Hepatocellular carcinoma; Hepa 1-6; Cancer stem cells; Cancer initiating cells; Epithelial-to-mesenchymal transition; Cellular plasticity; Epithelial-to-mesenchymal transition transcription factors; AML12
Core Tip Although existing therapies can initially eliminate the bulk population of a tumor, the stem cell properties of cancer stem cells (CSCs) enable them to survive and repopulate the tumor, resulting in disease relapse. Therefore, elimination of CSCs has the potential to improve patient outcomes and survival. Isolation and characterization of liver CSCs is essential for the selective targeting of this crucial population of cells. We report that the sphere culture method is a more precise and reliable tool for the enrichment of murine stem-like cells which relies on their functional property of anchorage-independent growth.
Publish Date 2017-09-20 01:02
Citation Jayachandran A, Shrestha R, Dhungel B, Huang IT, Vasconcelos MYK, Morrison BJ, Ramlogan-Steel CA, Steel JC. Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity. World J Stem Cells 2017; 9(9): 159-168
URL http://www.wjgnet.com/1948-0210/full/v9/i9/159.htm
DOI http://dx.doi.org/10.4252/wjsc.v9.i9.159
Full Article (PDF) WJSC-9-159.pdf
Full Article (Word) WJSC-9-159.doc
Manuscript File 34591-Review.docx
Answering Reviewers 34591-Answering reviewers.pdf
Audio Core Tip 34591-Audio core tip.mp3
Biostatistics Review Certificate 34591-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 34591-Conflict-of-interest statement.pdf
Copyright License Agreement 34591-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34591-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 34591-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 34591-Institutional review board statement.pdf
Peer-review Report 34591-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 34591-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 34591-Scientific misconduct check.pdf
Scientific Editor Work List 34591-Scientific editor work list.pdf