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Articles Published Processes
9/20/2017 1:02:37 AM | Browse: 1126 | Download: 1854
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Received |
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2017-05-09 09:22 |
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Peer-Review Started |
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2017-05-10 08:43 |
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To Make the First Decision |
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2017-06-14 00:47 |
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Return for Revision |
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2017-06-16 05:58 |
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Revised |
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2017-06-29 07:15 |
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Second Decision |
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2017-07-06 09:14 |
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Accepted by Journal Editor-in-Chief |
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2017-07-06 10:54 |
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Accepted by Executive Editor-in-Chief |
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2017-07-17 06:12 |
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Articles in Press |
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2017-07-17 06:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-09-13 06:03 |
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Publish the Manuscript Online |
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2017-09-20 01:02 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aparna Jayachandran, Ritu Shrestha, Bijay Dhungel, I-Tao Huang, Marianna Yumi Kawashima Vasconcelos, Brian J Morrison, Charmaine A Ramlogan-Steel and Jason C Steel |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Gallipoli Medical Research Foundation, Australia |
016092 |
| Cyril Gilbert Foundation, Australia |
017348 |
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| Corresponding Author |
Jason C Steel, PhD, Liver Cancer Unit, the University of Queensland School of Medicine and the Gallipoli Medical Research Institute, Greenslopes Private Hospital, Newdegate Street, QLD 4120, Brisbane, Australia. j.steel2@uq.edu.au |
| Key Words |
Hepatocellular carcinoma; Hepa 1-6; Cancer stem cells; Cancer initiating cells; Epithelial-to-mesenchymal transition; Cellular plasticity; Epithelial-to-mesenchymal transition transcription factors; AML12 |
| Core Tip |
Although existing therapies can initially eliminate the bulk population of a tumor, the stem cell properties of cancer stem cells (CSCs) enable them to survive and repopulate the tumor, resulting in disease relapse. Therefore, elimination of CSCs has the potential to improve patient outcomes and survival. Isolation and characterization of liver CSCs is essential for the selective targeting of this crucial population of cells. We report that the sphere culture method is a more precise and reliable tool for the enrichment of murine stem-like cells which relies on their functional property of anchorage-independent growth. |
| Publish Date |
2017-09-20 01:02 |
| Citation |
Jayachandran A, Shrestha R, Dhungel B, Huang IT, Vasconcelos MYK, Morrison BJ, Ramlogan-Steel CA, Steel JC. Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity. World J Stem Cells 2017; 9(9): 159-168 |
| URL |
http://www.wjgnet.com/1948-0210/full/v9/i9/159.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v9.i9.159 |
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