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Articles Published Processes
9/7/2017 8:51:55 AM | Browse: 970 | Download: 1360
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Received |
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2017-05-10 08:43 |
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Peer-Review Started |
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2017-05-12 19:01 |
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To Make the First Decision |
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2017-06-05 00:25 |
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Return for Revision |
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2017-06-11 10:56 |
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Revised |
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2017-06-23 19:01 |
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Second Decision |
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2017-07-21 07:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-07-24 08:04 |
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Articles in Press |
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2017-07-24 08:04 |
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Publication Fee Transferred |
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2017-08-15 06:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-08-25 06:18 |
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Publish the Manuscript Online |
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2017-09-07 08:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
High yield reproducible rat model recapitulating human Barrett’s carcinogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Daisuke Matsui, Ashten N Omstead, Juliann E Kosovec, Yoshihiro Komatsu, Emily J Lloyd, Haley Raphael, Ronan J Kelly, Ali H Zaidi and Blair A Jobe |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Blair A Jobe, MD, Esophageal and Lung Institute, Allegheny Health Network, 4600 North Tower, 4800 Friendship Avenue, Pittsburgh, PA 15224, United States. blair.jobe@ahn.org |
| Key Words |
Esophageal adenocarcinoma; Gastroesophageal reflux disease; Levrat; Esophagojejunostomy; Experimental rat model; Mucin genes; Cytokeratins |
| Core Tip |
The current study reportsrefined surgical techniques with improved tumor burdens for the modified Levrat model of end-to-side esophagojejunostomy in a rat for future in vivo studies of esophageal adenocarcinoma (EAC). For the first time, the model was established with significantly reduced mortality and morbidity and further validated through evaluation of conserved EAC disease progression markers, such as mucin and cytokeratins. The reported approach will allow for broader adoption of the model to allow for greater understanding of the complete disease progression spectrum from Barrett’s esophagus to metastatic EAC and aid in the development of novel therapeutics. |
| Publish Date |
2017-09-07 08:51 |
| Citation |
Matsui D, Omstead AN, Kosovec JE, Komatsu Y, Lloyd EJ, Raphael H, Kelly RJ, Zaidi AH, Jobe BA. High yield reproducible rat model recapitulating human Barrett’s carcinogenesis. World J Gastroenterol 2017; 23(33): 6077-6087 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i33/6077.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i33.6077 |
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